Abstract
Recent data from our laboratory support the notion that the enzyme dipeptidyl peptidase IV (DPPIV) plays an important role in the pathophysiology of heart failure (HF). DPPIV is a serine protease that cleaves and inactivates a variety of peptides that exert cardioprotective effects, including glucagon-like peptide-1 (GLP-1), brain natriuretic peptide (BNP) and stromal cell-derived factor-…