Abstract
Cross-linkers are natural or synthetically produced substances that improve the number of collagen inter- and intra-molecular bonds as well as the number of inter collagen fibril bonds. Among these substances are glutaraldehyde (GA), protocianidine (PA) and carbodiimide (1-Etil-3-[3-dimetilaminopropil] carbodiimide hydrochloride or EDC). By increasing the strength of collagen fibrils thes…