Abstract
Valproic Acid (VPA) is a well known Histone Deacetylase (HDAC) inhibitor. Currently, in addition to HDAC inhibition, DNA demethylation is being considered as part of the VPA action on certain cell types. In the present work, the process of DNA demethylation following VPA treatment will be studied in detail in HeLa cells, in which chromatin remodeling attributed to HDAC inhibition has been…