CV Lattes
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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor at the Federal University of ABC (UFABC), Center for Natural and Human Sciences (CCNH). He has multidisciplinary experience in bioactive compounds that interfere Complex Biological Systems. He is interested to study: (1) Identification of synthetic or natural biomolecules with functional properties of pharmaceutical interest; (2) Understanding the morphofunctional complexity of biological organs and systems their interference in the presence of biomolecules of interest to the national and / or international productive sector; (3) Studies of potential biomolecules applied in innovative or incremental strategies for the diagnosis or treatment of different dysfunctions to improve the quality of human life. (Source: Lattes Curriculum)
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Neuroprotection mediated by proline-rich oligopeptides (PROs), derived from Bothrops jararaca snake venom, has been reported when different neuronal cell cultures are pre-treated with PROs and then exposed to oxidative stress. The neuroprotection of PRO-10c (<ENWPHPQIPP) is related to the increased synthesis of L-arginine, its metabolism and the formation of agmatine and polyamines which …
Neurodegenerative diseases promote the progressive loss of different regions of the brain from many molecular and cellular events related to oxidative stress, mitochondrial dysfunction, misfolding of proteins, excitotoxicity, and inflammation. Neuroprotective therapies based on peptides derived from complex natural substances that are capable of improving cell viability or mitochondrial f…
The number of researchers assigned to the CCNH has expanded every year, as well as the need for space for research. Block L will delivery an addition 1900 m² of space intended for research in the Santo André campus of UFABC. This space will allow the proper allocation of personal, improving the working conditions for a number of researches that are working in a sub-optimal conditions. The…
The Bradykinin Potentiating Peptides (BPPs) were the first natural inhibitors of angiotensin-converting enzyme somatic (ACEs) described. Testicular isoform of ACE (ACEt) has been described and is distributed only in the germ cells during spermatogenesis in testis, as well as in sperm. Recently, our group has characterized the effects of BPP-10c and other BPPs on spermatogenesis of mice, t…
Neuroprotection mediated by proline-rich oligopeptides (PROs), derived from Bothrops jararaca snake venom, has been reported when different neuronal cell cultures are pre-treated with PROs and then exposed to oxidative stress. The neuroprotection of PRO-10c (<ENWPHPQIPP) is related to the increased synthesis of L-arginine, its metabolism and the formation of agmatine and polyamines which …
The recent discovery of temperature sensitive transient receptor (TRP) channels was of extreme importance for a better understanding of the mechanisms of body temperature regulation. Among TRP channels, TRPM8 is characterized as the main channel involved in thermoregulation in responses to cold stimuli, being activated by temperatures below ~ 25°C in vitro and also by the exogenous agonis…
Alzheimer's disease (AD) is a neurodegenerative disorder that presents one of its first symptoms the loss of recent memory, which can progress to a great cognitive decline. It can be divided in two forms: familial and sporadic. In both cases, one of its main histopathological markers are the neurofibrillary tangles (NFTs) of Tau protein. Some animals models were developed to study of AD, …
| 2 / 2 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 2 | Completed scholarships in Brazil |
| 13 / 7 | All research grants and scholarships |
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