Mario Ferretti Filho

• Abstract

  The aim of this study is to evaluate the serie concentration of HMGB1 in OÁ patients before and after rehabilitation program and to correlate the levels of this biomarker with the patients' functional capacity values. The hypothesis of this study is that, rehabilitation program attenuates inflammation systemically and locally in patients with knee osteoarthritis by suppressing the HMGB1 l…

  Response of osteoarthritis biomarkers after a rehabilitation program, AP.R

• Abstract

  The objectives of this study are to: 1) assess the cost-effectiveness of second opinion for spine surgery; 2) evaluate the effectiveness of conservative and surgical treatments for degenerative lumbar spine diseases; 3) define objective criteria of conservative and surgical treatment using evidence-based medicine; 4) evaluate the prognostic of biomarkers; 5) compare the diagnoses and reco…

  Second opinion column in the surgery indications: evaluation of cost-effectiveness, AP.PITE

• Abstract

  Osteoarthritis (OA), a significant problem for Public Health, manly related to aging, causes articular cartilage (CA) degeneration, joint pain and consequently locomotion disability. This process is accompanied by increased presence of inflammatory cytokines and proteolytic molecules in the tissue, leading to extracellular matrix degeneration and decreased CA function. Current therapies f…

  Local and systemically administered mesenchymal cells regenerative capacity on osteoartrhitis animal model, AP.R

(Only some records are available in English at this moment)

• Abstract

  Osteoarthritis (OA), a significant problem for Public Health, manly related to aging, causes articular cartilage (CA) degeneration, joint pain and consequently locomotion disability. This process is accompanied by increased presence of inflammatory cytokines and proteolytic molecules in the tissue, leading to extracellular matrix degeneration and decreased CA function. Current therapies f…

  Local and sistemicaly administrated mesenchymal cells regenerative capacity on osteoartrhitis animal model., BP.DR

• Abstract

  Tonia Vincent's group has previously shown that the cartilage matrix releases sequestered growth factors, including FGF2 and latent TGFbeta, in response to mechanical injury. Latent TGFbeta requires the cell surface receptor, betaglycan, also known as TGFbetaR3 in order to become activated. Repair of the cartilage in vivo is dependent on FGF2 as mice deficient in this growth factor are un…

  To investigate how FGF2 and latent TGFBeta controls the migration and differentiation of mesenchymal stem cells at the site of cartilage injury, BE.EP.DR