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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Sayuri Miyamoto holds a Bachelors degree in Pharmacy from the University of São Paulo (USP). She has international training and research experience in Japan, including a research internship at the National Food Research Institute (NFRI-MAFF, Tsukuba) and an M.Sc. in Nutrition from the University of Tokushima. She earned her Ph.D. in Biological Sciences (Biochemistry) and completed postdoctoral training at the Institute of Chemistry, USP and in Japan. She has been a faculty member in the Department of Biochemistry at the Institute of Chemistry (IQ-USP) since 2007 and has served as an Associate Professor (A3) since 2021. She is internationally recognized (h-index 40; >8,000 citations) for her research in lipid metabolism and redox biology, with emphasis on lipidomics/redox lipidomics by mass spectrometry, oxidized lipids as biomarkers and signaling mediators, and cell-death mechanisms associated with lipid peroxidation (including ferroptosis) in neurodegenerative diseases, cancer, and infectious diseases.She is a Principal Investigator of the CEPID Redox Processes in Biomedicine (FAPESP 2013/07937-8, 2013-2026), the INCT-Quantitative and Precision Methodologies in Redox Biomedicine (Grant No. 408213/2024-8, 2025-2030), and CoMETA (USP Center of Metabolism). She coordinates a multi-user high-resolution mass spectrometrybased platform for redox lipidomics analyses, supporting academic projects and industry demands, including EMBRAPII-funded projects and international projects (NDR Inc.). She served on the Council of the Society for Redox Biology and Medicine (20202024) and is part of the Board of the Brazilian Society for Biochemistry and Molecular Biology (First Treasurer, 2022; First Secretary, 2023present). She also serves on the editorial boards of international journals, including Scientific Reports, Chemical Research in Toxicology, and Advances in Redox Research. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Bioquímicos detectan alteraciones en la retina asociadas a la ceguera en bebés prematuros |
| Biochemists identify retinal changes associated with blindness in preterm infants |
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The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
Docosahexaenoic acid (DHA) and cholesterol are two important lipids found in abundance in the nervous system. Both are crucial for brain function and alterations in their quantity and/or oxidation are associated with neurodegenerative diseases. Despite of their relevance, at the moment little is known about the role of these lipids and their oxidation products in Amyotrophyc Lateral Scler…
(Only some records are available in English at this moment)
Introduction: Sickle cell anemia (SCA) is a genetic disease affecting thousands of people worldwide. In Brazil, the life expectancy of individuals with the disease is lower than the national average. With a complex pathophysiology, hemolytic and vaso-occlusive events result in painful crises, the leading cause of hospitalization. Polyunsaturated fatty acids, such as arachidonic acid (ARA)…
The amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by death of motor neurons in brain and spinal cord, leading to muscular atrophy, paralysis, and death. Importantly, alterations in lipid metabolism due to chronic inflammation and oxidative stress are strongly linked to ALS. The central nervous system (CNS) is enriched in polyunsaturated fatty acids (PUF…
Aging is a risk factor for the development and intensification of several diseases including viral infections such as that caused by Sars-Cov-2. Lipids are very important molecules. They act in inflammatory signaling and are also a source for viral replication. Lipids are necessary to produce double-layer membranes (DMVs) that will protect the virus from the host's immune system. Consider…
Ferroptosis is a type of non-apoptotic cell death characterized by iron-dependent lipid peroxidation. Recent studies show a close relationship between cholesterol metabolism, lipid droplet accumulation and sensitivity to ferroptosis, however, little is known about its impact on brain cells. This project aims to evaluate the role of lipids such as free and esterified cholesterol, in additi…
In mammals, formation and detoxification of oxidized lipids are catalysed, among other enzymatic systems, by lipoxygenases and peroxidases, respectively. Some human lipoxygenases, including 5-lipoxygenase (5-LOX) and 15-lipoxygenases (15-LOX-1 and 15-LOX-2), participate in the biosynthesis of pro-inflammatory and pro-resolution lipid mediators and play important roles as modulators of inf…
Linoleic acid (LA) is a polyunsaturated fatty acid (PUFA) of the omega-6 family that can be found in many foods and vegetable oils. Due to the growth in soy production and consumption of processed foods, LA consumption has grown exponentially since the beginning of the 20th century. Once obtained from the diet, LA can be stored in lipid2 droplets in the form of triacylglycerol or choleste…
(Only some records are available in English at this moment)
Respiratory infections caused by coronavirus were responsible for three outbreaks in 2003, 2012 and 2019. Covid-19 caused by Sars-Cov-2 was responsible for more than 6.9 million deaths. The understanding of virus metabolism in the organism could lead to the production of new drugs that prevent viral contamination at pandemic levels. Lipid metabolism have been showing high relevance for vi…
Oxidized lipids are frequently linked to pathological conditions due to their role as modulators of inflammation and oxidative stress. More recently, oxidized lipids have been reported as key regulators of ferroptosis, a form of regulated cell death triggered by accumulation of lipid hydroperoxides in the cell membrane. Ferroptosis is under intensive investigation in diseases, with cancer…
Cholesterol is a neutral lipid widely found in the cell membrane, where it influences in the membrane fluidity, organization and in cell signaling events. Since cholesterol is known to play structural and regulatory functions in the membrane, its physiological concentration is strictly controlled by the cell. An increase in the mitochondrial cholesterol, for instance, has been associated …