CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy-Biochemistry from the Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (1999-2003), Master's (2003-2005) and Ph. Professor (2016) in Pharmacology at the Faculty of Medicine of Ribeirão Preto, University of São Paulo. Sabbatical (Visiting Professor) at Harvard Medical School, Department of Immunology as part of the CAPES/Harvard Young Visiting Professor program. He was an Affiliate member of the Brazilian Academy of Sciences. He has been awarded national and international scientific awards, including the prestigious 2020 Patrick D. Wall Young Investigator Award for Basic Science from the International Association for the Study of Pain (IASP). He is currently an Associate Professor at FMRP-USP. Academic editor of international journals such as Communications Biology, Brain Research, Frontiers in Pharmacology and Inflammation Research. Has experience in Pharmacology, with emphasis on Pharmacology of Inflammation and Pain, working mainly on the following topics: Neurobiology of inflammatory and neuropathic pain and Molecular mechanisms involved in the effects of analgesics. (Source: Lattes Curriculum)
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This decade begins with a worldwide health emergency, the new coronavirus pandemic, cause of severe acute respiratory syndrome 2 (SARS-CoV2). Until this date, there are more than 900,000 positive cases that have resulted in more than 44,000 deaths in 180 countries. In view of these epidemiological data, strategies are needed to contain the transmission of the virus and mainly effective al…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
Diseases with an inflammatory component, including arthritis and sepsis, are a complex and heterogeneous group of disorders that affect the world population. The current options for the treatment of these diseases are still limited and in some cases, ineffective due to limited understanding of the mechanisms underlying these disorders. Thus, the overall aim of this proposal is to extend o…
For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizi…
Our project consists of 3 subprojects which investigate a) mechanisms involved in the genesis of chronic and acute inflammatory pain as well as the mechanisms involved in the effects of different analgesics; b) mediators involved in the migration of neutrophils in different models of immune inflammation; c) mechanisms involved in the failure of the migration of neutrophils to the site of …
Wallerxian degeneration (WD) is an important process of myelin destruction and destruction after a mechanical trauma after a trauma, or immune in the peripheral system, being important for the functional recovery of the tissue afterwards. The cytokine IL-33 belongs to the IL-1 superfamily group and is expressed by hematopoietic cells and has already been described as being important in di…
Injuries and diseases that affect the somatosensory system lead to the neuropathic pain development. The genesis and maintenance of this condition is determined by changes in the nociceptive sensory apparatus that increase painful sensitivity. Much of these changes are mediated by the activity of immune cells in the central and peripheral pain modulating sites, such as the spinal cord or …
(Only some records are available in English at this moment)
Pain is a response usually generated by a noxious stimulus capable of generating tissue damage. The pain pathway starts at nociceptive sensory neurons, whose somas are located at the dorsal root ganglion, and project to the periphery and the spinal cord, in addition to the cerebral cortex, where nociceptive information is interpreted as pain. Different types of sensitive fibers, such as C…
Astrocytes are the most abundant glial cells in the central nervous system (CNS) and are responsible for the energy supply of neurons. In situations of CNS disorders, besides inducing inflammatory response by the release of cytokines and chemokines, they are also able to alter their metabolism to maintain cerebral homeostasis. O-Glycosyl Transferase (OGT) is an enzyme of the hexamine path…
(Only some records are available in English at this moment)
Neuropathic pain is a disease of the somatosensory system that can result from different etiological factors such as mechanical, biological, metabolic, or chemical insults. Chemotherapeutic agents used to treat cancer can cause neuropathic pain (CINP) due to their neurotoxicity to primary sensory neurons, causing aberrant functioning of these cells and leading to long-lasting pain in canc…
Microglia and astrocytes are the most extensively studied cells beyond neurons in the CNS and are in a dynamic communication in healthy and diseased brains. Chronic neuroinflammation can cause synaptic dysfunction and neuronal death, being a common feature of neurodegenerative diseases, such as Alzheimer's disease (AD). In the past years, it has become evident that metabolism regulates th…
Autophagy is an important homeostatic cellular process, responsible for the lysosomal degradation of non-functional proteins and organelles. Moreover, recently it is well accepted that autophagy has multiple effects on immune system. Interestingly, genetic ablation and pharmacological inhibition of autophagic machinery have been described to induce phenotypic modifications in immune cells…
Chronic pain treatment is still a challenge to researchers and clinicians. Much has been elucidated regarding to the physiopathology of several painful conditions, but less has been developed aiming new drugs to mainly control neuropathic pain. Also, much has explored about phenotypic changes caused by genetic and protein expression shift in nociceptive system, but nothing has been mentio…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 13 / 13 | Ongoing scholarships in Brazil |
| 25 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 50 / 46 | All research grants and scholarships |
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