CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Farmácia-Bioquímica from Universidade de São Paulo (2003), master's at Pharmacology from Universidade de São Paulo (2005) and doctorate at Pharmacology from Universidade de São Paulo (2008). Has experience in Pharmacology, acting on the following subjects: hypernociception, electronic pressure-meter, hyperalgesia, prostaglandin and teste de pressao crescente na pata de camundongos. (Source: Lattes Curriculum)
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This decade begins with a worldwide health emergency, the new coronavirus pandemic, cause of severe acute respiratory syndrome 2 (SARS-CoV2). Until this date, there are more than 900,000 positive cases that have resulted in more than 44,000 deaths in 180 countries. In view of these epidemiological data, strategies are needed to contain the transmission of the virus and mainly effective al…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
Diseases with an inflammatory component, including arthritis and sepsis, are a complex and heterogeneous group of disorders that affect the world population. The current options for the treatment of these diseases are still limited and in some cases, ineffective due to limited understanding of the mechanisms underlying these disorders. Thus, the overall aim of this proposal is to extend o…
For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizi…
Our project consists of 3 subprojects which investigate a) mechanisms involved in the genesis of chronic and acute inflammatory pain as well as the mechanisms involved in the effects of different analgesics; b) mediators involved in the migration of neutrophils in different models of immune inflammation; c) mechanisms involved in the failure of the migration of neutrophils to the site of …
Pain is a response usually generated by a noxious stimulus capable of generating tissue damage. The pain pathway starts at nociceptive sensory neurons, whose somas are located at the dorsal root ganglion, and project to the periphery and the spinal cord, in addition to the cerebral cortex, where nociceptive information is interpreted as pain. Different types of sensitive fibers, such as C…
Bone is a rigid tissue, but it is in continuous remodeling activity, which is essential for the renewal and maintenance of its integrity throughout the individual's life. Bone remodeling is a metabolic process characterized by a precise balance between bone matrix degradation (resorption) and synthesis, which involves the activity of several specialized cells, among which osteoclasts and …
(Only some records are available in English at this moment)
Astrocytes are the most abundant glial cells in the central nervous system (CNS) and are responsible for the energy supply of neurons. In situations of CNS disorders, besides inducing inflammatory response by the release of cytokines and chemokines, they are also able to alter their metabolism to maintain cerebral homeostasis. O-Glycosyl Transferase (OGT) is an enzyme of the hexamine path…
Astrocytes are the most abundant glial cells of the Central Nervous System (CNS), essential for the maintenance of brain homeostasis. It has been indisputable the astrocytes participation in experimental models of multiple sclerosis (EAE) and neuropathic pain, in which their activation contribute to the amplification of the inflammatory response. In view of a neuroinflammatory condition, …
Macrophages are cellular components of the immune system that reside in the most diverse tissues and are described as cells that play a fundamental role in several immune response processes such as maintaining homeostasis and modulating inflammatory processes. The concept that all tissue-resident macrophages are derived from precursors of bone marrow and circulating monocytes has been dra…
(Only some records are available in English at this moment)
Microglia and astrocytes are the most extensively studied cells beyond neurons in the CNS and are in a dynamic communication in healthy and diseased brains. Chronic neuroinflammation can cause synaptic dysfunction and neuronal death, being a common feature of neurodegenerative diseases, such as Alzheimer's disease (AD). In the past years, it has become evident that metabolism regulates th…
Autophagy is an important homeostatic cellular process, responsible for the lysosomal degradation of non-functional proteins and organelles. Moreover, recently it is well accepted that autophagy has multiple effects on immune system. Interestingly, genetic ablation and pharmacological inhibition of autophagic machinery have been described to induce phenotypic modifications in immune cells…
Chronic pain treatment is still a challenge to researchers and clinicians. Much has been elucidated regarding to the physiopathology of several painful conditions, but less has been developed aiming new drugs to mainly control neuropathic pain. Also, much has explored about phenotypic changes caused by genetic and protein expression shift in nociceptive system, but nothing has been mentio…
One of the main challenges in analgesic therapy is the treatment of chronic pain. This type of pain is characterized as a debilitating disease, and affects more than 100 million Americans. It is believed that about one third of the population will have some type of chronic pain throughout life. Among types of chronic pain, we highlight neuropathic pain. Since the 80s, the pronociceptive e…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 11 / 11 | Ongoing scholarships in Brazil |
| 23 / 19 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 45 / 41 | All research grants and scholarships |
| Associated processes | |
VIVANCOS, G. G.; VERRI JUNIOR, WALDICEU A.; SCHIVO, I. R. S.; PARADA, C. A.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO. MATTAR. An electronic pressure-meter nociception paw test for rats. Brazilian Journal of Medical and Biological Research, v. 37, n. 3, p. 391-399, Mar. 2004.
VERRI JUNIOR, WALDICEU A.; VIVANCOS, G. G.; MOREIRA, I. F.; REIS, S.; PARADA, C. A.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO. MATTAR. An electronic pressure-meter nociception paw test for mice. Brazilian Journal of Medical and Biological Research, v. 37, n. 3, p. 401-407, Mar. 2004.
KUSUDA, RICARDO; CARREIRA, ELEONORA UCHOA; ULLOA, LUIS; CUNHA, FERNANDO QUEIROZ; KANASHIRO, ALEXANDRE; CUNHA, THIAGO MATTAR. Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway. Brain Research, v. 1727, JAN 15 2020. (12/23846-0, 13/08216-2, 11/20343-4, 10/16823-8)
ANIBAL SILVA, CONCEICAO ELIDIANNE; GUIMARAES, RAFAELA MANO; CUNHA, THIAGO MATTAR. Sensory neuron-associated macrophages as novel modulators of neuropathic pain. PAIN REPORTS, v. 6, n. 1, 2021. (20/05446-0, 13/08216-2, 19/13829-0, 17/50419-9)
SILVA, MARIA C.; DAVOLI-FERREIRA, MARCELA; MEDINA, TIAGO S.; SESTI-COSTA, RENATA; SILVA, GRACE K.; LOPES, CARLA D.; CARDOZO, LUCAS E.; GAVA, FABIO N.; LYRONI, KONSTANTINA; DIAS, FABRICIO C.; et al. Canonical PI3K gamma signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. NATURE COMMUNICATIONS, v. 9, APR 17 2018. (13/08216-2, 12/14524-9, 11/09488-0)
BRITO ARAGAO, MARIA GERUSA; FERNANDES GOMES, FRANCISCO ISAAC; MAIA PAIXAO-DE-MELO, LETICIA PINHO; MILORI CORONA, SILMARA APARECIDA. Brazilian dental students and COVID-19: A survey on knowledge and perceptions. EUROPEAN JOURNAL OF DENTAL EDUCATION, FEB 2021. (20/02658-7, 19/14285-3)
ZANATA, GRAZIELE C.; PINTO, LARISSA G.; DA SILVA, NICOLE R.; LOPES, ALEXANDRE H. P.; DE OLIVEIRA, FRANCISCO F. B.; SCHIVO, IEDA R. S.; CUNHA, FERNANDO Q.; MCNAUGHTON, PETER; CUNHA, THIAGO M.; SILVA, RANGEL L.. Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel-associated acute pain syndrome in mice. EUROPEAN JOURNAL OF PAIN, v. 25, n. 1, p. 189-198, JAN 2021. (13/08216-2, 17/50419-9)
GOMES, FRANCISCO ISAAC F.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Peripheral nitric oxide signaling directly blocks inflammatory pain. Biochemical Pharmacology, v. 176, n. SI, JUN 2020. (13/08216-2, 19/14285-3)
(References retrieved automatically from State of São Paulo Research Institutions)
CECÍLIA, Flávia Viana Santa. Papel dos receptores intracelulares NOD1 e NOD2 na gênese da dor neuropática. Tese (Doutorado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (11/14277-9)
REIS, Dênis Augusto Santana. Ativação supraespinal da via das quinureninas contribui para a manutenção da dor neuropática. Dissertação (Mestrado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/07968-0)