CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Faculdade de Medicina da Pontifícia Universidade Católoca de São Paulo (1984) and doctorate at Radiologia from Faculdade de Medicina da Universidade de São Paulo (1992). Has experience in Medicine, focusing on Medicine (Source: Lattes Curriculum)
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Radiopharmaceuticals are medicines with diagnostic or therapeutic purposes that, when ready for use, contain one or more radionuclides. Radiopharmaceuticals with a short half-life (less than two hours) are produced in cyclotrons that can be present in public and private institutions since the break of the Brazilian government monopoly in 2008. This break in monopoly enabled the installati…
Prostate cancer is the second leading cause of male cancer mortality in Brazil. In recent years, prostate-specific membrane antigen (PSMA)-targeted radioligand therapy has emerged as a promising option for patients suffering from mCRPC and do not respond to previously recommended therapies. Indeed, 45-60% of patients with mCRPC respond to 177Lu-PSMA therapy as demonstrated by several clin…
The diagnosis of Alzheimer's disease (AD), a great public health problem, is imprecise and delayed (since the neurodegenerative processes begin years before the appearance of symptoms). The validation of AD biomarkers has the potential to afford early diagnosis and novel treatments. This project aims to investigate, in a multidisciplinary and translational fashion, the accumulation of b-a…
The low oxigenation (hypoxia) drastically changes the cell metabolism and the production way of ATP, changing various intracell parameters. Due the tumor growing and the formation of aberrant vessels, there are a vicious cicle of hypoxia-normoxia to order to suply nutritional needs of the cells; this phenomenon calls "intermittent hypoxia". This stimulates and allows cells to develop leak…
As the life expectancy is increasing in the general population, dementia has becoming a high prevalent condition in the elderly. The clinical intermediate phase situated between normal cognitive changes related to aging and dementia, especially Alzheimer's disease (AD), is known as Mild Cognitive Impairment (MCI). The possible progression of MCI towards dementia makes the characterization…
(Only some records are available in English at this moment)
Brain aging is associated with the accumulation of beta-amyloid, a protein linked to improper processing and the formation of insoluble plaques that disrupt cellular communication, impairing cognitive function. Beta-amyloid accumulation is connected to both brain aging and Alzheimer's disease (AD), which accounts for the majority of dementia cases worldwide. In individuals with Down syndr…
The use of 18F-fluordeoxiglicose (FDG) allows malignant processes to become clearly identified on images of positron emission tomography (PET) as areas of increased glycolytic metabolism. Unfortunately, certain benign processes also exhibit high avidity for radioactive glucose and they may cause misinterpretations. Among them, we highlight the inflammatory process, which often generates f…
| 2 / 2 | Ongoing grants |
| 15 / 7 | Completed research grants |
| 5 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 13 | All research grants and scholarships |
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