Carlos Alberto Buchpiguel

• Abstract

  The diagnosis of Alzheimer's disease (AD), a great public health problem, is imprecise and delayed (since the neurodegenerative processes begin years before the appearance of symptoms). The validation of AD biomarkers has the potential to afford early diagnosis and novel treatments. This project aims to investigate, in a multidisciplinary and translational fashion, the accumulation of b-a…

  Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers, AP.TEM

• Abstract

  The low oxigenation (hypoxia) drastically changes the cell metabolism and the production way of ATP, changing various intracell parameters. Due the tumor growing and the formation of aberrant vessels, there are a vicious cicle of hypoxia-normoxia to order to suply nutritional needs of the cells; this phenomenon calls "intermittent hypoxia". This stimulates and allows cells to develop leak…

  Assessment of radiopharmaceuticals to determine hypoxia in cells and tumors of B16F10 murine melanoma, AP.R

• Abstract

  As the life expectancy is increasing in the general population, dementia has becoming a high prevalent condition in the elderly. The clinical intermediate phase situated between normal cognitive changes related to aging and dementia, especially Alzheimer's disease (AD), is known as Mild Cognitive Impairment (MCI). The possible progression of MCI towards dementia makes the characterization…

  Correlation analysis of changes in structural volume, perfusion and glucose metabolism in Alzheimer's disease, mild cognitive impairment and normal aging, AP.R

(Only some records are available in English at this moment)

• Abstract

  The use of 18F-fluordeoxiglicose (FDG) allows malignant processes to become clearly identified on images of positron emission tomography (PET) as areas of increased glycolytic metabolism. Unfortunately, certain benign processes also exhibit high avidity for radioactive glucose and they may cause misinterpretations. Among them, we highlight the inflammatory process, which often generates f…

  Action of indomethacin on the response of inflammatory process experimentally induced. A study using positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG), BP.IC
• Evaluation of [[99mTc]glucarate]- and (18F)FAZA radiopharmaceuticals for determining hypoxia in murine melanoma B16F10 cells and tumors, BP.MS

• Fdg-pet staging and follow-up of primary lung carcinoma, BE.PQ