Celso Eduardo Benedetti

• Abstract

  One of the major concerns regarding human bacterial infections nowadays is the escalating development of antimicrobial resistance (AMR) that results primarily from the indiscriminate use of antibiotics, both in the clinic and agriculture. Despite all the advances in medicine since the discovery of penicillin, AMR has become one of the major public health problems in the world. This scenar…

  Discovery and development of new antimicrobial compounds against gram-negative bacteria resistant to carbapenems and cephalosporins, AP.R

• Abstract

  Xanthomonas citri, the causal agent of citrus canker, employs the type III secretion system to inject transcription activator-like (TAL) effectors into the host cell. Such proteins, known as PthAs, act as transcription factors activating target genes that promote pathogen growth and contribute to disease development. However, besides activating target genes in the host, we found that PthA…

  Structural and functional analysis of the RNA polymerase III repressor Maf1 involved in cell growth control and pathogen response in plants, AP.R

• Abstract

  The citrus industry is one of the most important agribusiness sectors in Brazil benefiting not only the citrus growers, exporters and consumers, but the society in general with incomes and jobs. However, despite its economic strength, the sector is facing several challenges and production costs have risen annually due mostly to the need of controlling numerous citrus diseases with agroche…

  Molecular mechanisms involved in pathogen adaptation and virulence, host resistance and symptom development in citrus-bacteria interactions, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  Given the relevance of Gram-negative bacteria as critical plant and animal pathogens, our group has synthetized and tested several quinazoline derivatives with antimicrobial action against these microorganisms. One such compound, named QX1, showed antimicrobial activity against several Xanthomonas pathogens. Although the antimicrobial activity of many quinazoline compounds is known, the p…

  Identification of the mode of action of a quinazoline with antimicrobial activity against phytopathogenic Xanthomonas species, BP.IC

• Abstract

  Phytopathogenic bacteria utilizes several strategies to infect, colonize and cause disease in plants. Xanthomonas citri pv citri (Xcc), the causal agent of citrus canker, employs the type III secretion system to inject effector proteins of the PthA family into the host cell. Such proteins act as transcription factors activating target genes that would promote pathogen growth and contribut…

  Functional analysis of CsMAF1, an RNA polymerase III repressor involved in cell growth control and pathogen response in plants, BP.PD

• Abstract

  CAF1 (CCR4-NOT-associated factor), also known as CNOT7, is a component of the eukaryotic CCR4-NOT complex that regulates not only the synthesis but also the destruction of mRNAs in the cell. CAF1 is conserved from yeast to man and it presents deadenylase activity upon the poli(A) tail of mRNAs. Thus, CAF1 plays an essential role in gene regulation through an mRNA decay mechanism. In a pre…

  Synthesis and characterization of inhibitors for human and citrus deadenylase CAF1 (CNOT7), BP.IC

(Only some records are available in English at this moment)

• Abstract

  Transcription activator-like (TAL) effectors from Xanthomonas pathogens act as transcription factors in plant cells; however, how TAL effectors activate host transcription is unknown. We found previously that PthA4, the main TAL effector of the citrus canker pathogen Xanthomonas citri, specifically binds to citrus MAF1 (CsMAF1), an RNA Pol III repressor that controls ribosome biogenesis a…

  Metabolic profile analysis of sweet orange in response to X. citri infection and genetically modified plants that silence or overexpress the maf1 gene, BE.EP.PD