Célia Harumi Tengan

• Abstract

  Nitric oxide is a free radical that interested several areas of research in medicine because it is involved in the pathogenesis of different diseases such as cardiovascular, respiratory, neurodegenerative, infectious diseases and cancer. One of the main actions of nitric oxide in mitochondria is the inhibitory effect on the respiratory chain, acting in the control of mitochondrial functio…

  Evaluation of the relationship between protein nitration and mitochondrial abnormalities, AP.R

• Abstract

  Mitochondrial Diseases (MD) are a heterogeneous group of diseases characterized by alterations of the mitochondrial metabolism that result, mainly, in nervous and muscular system impairment. In muscle biopsies of the patients with MD, there is a histological modification characterized by the accumulation of structurally abnormal mitochondria in muscle fibers (ragged red fibers- RRF). This…

  Study of the relationship between nitric oxide synthesis, mitochondrial biogenesis and apoptosis in skeletal muscle, AP.R

• Abstract

  There is great difficulty in the diagnosis of mitochondrial encephalopathies, mainly due to the fact that muscle biopsy is normal in these forms of mitochondrial diseases. The main causes of mitochondrial encephalopathies include complex I deficiency and molecular investigation is very difficult because there are many genes involved. The most important diagnostic method in this form of mi…

  Contribution of respiratory chain protein studies in the molecular characterization of mitochondrial diseases, AP.R

(Only some records are available in English at this moment)

• Abstract

  Mitochondrial Diseases (MD) are a heterogeneous group of diseases characterized by alterations of the mitochondrial metabolism that result, mainly, in nervous and muscular system impairment. In the muscle biopsy of the patients with MD, generally, there is a histological modification characterized by the accumulation of structurally abnormal mitochondria in the muscular fiber (Ragged Red …

  In situ and in vitro analysis of nitric oxide, apoptosis and mitochondrial biogenesis in mitochondrial diseases and C2C12 myoblast cell line, BP.DD

• Abstract

  It is believed that mitochondrial DNA (mtDNA) age-related deletions are caused by oxidative damage and that respiratory chain defects would lead to increased predisposition to these lesion due to increased free radical generation. Recent studies have shown mitochondrial production of nitric oxide (NO), a free radical that also participates in several physiological processes. In mitochondr…

  Evaluation of nitric oxide synthesis in cell lines with respiratory chain defects, BP.IC