CV Lattes
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Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
BS in Chemistry from IQSC-USP, PhD in Physical Chemistry from IQSC-USP and post-doctor in Medicinal and Computational Chemistry from IFSC-USP. Currently, she is associate professor at USP and scholarship of research productivity (CNPq). Research interests: medicinal chemistry, computational chemistry, molecular modeling, and cancer. Referee of various scientific journals and funding agencies. The researcher has more than 140 articles published in scientific journal, papers published in national and international conferences, book chapters and coordination of projects funded by FAPESP and CNPq. She was awarded the prize "For Women in Science", awarded by L'Oreal, UNESCO and Brazilian Academy of Sciences. (Source: Lattes Curriculum)
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Infectious diseases are a significant burden on public health and economic stability of societiesall over the world. The threat posed by infectious diseases is further deepened by the continuedemergence of new, unrecognized, and old, re-emerging infectious diseases. This becameeven more prominent by the continuously increasing air traffic and the resulting possible globaldissemination of …
To develop a new medicine, investigators must analyze the biological targets of a given disease, discover and develop drug candidates for these targets, performing in parallel, biological laboratory tests to validate the drug effectiveness and side effects. The Quantitative Study of Activity-Structure Relationships (QSAR) involves building regression models that relate a set of descriptor…
Neglected diseases are considered a serious and growing public health problem in developing countries because of the increased prevalence, morbidity, and mortality. Thus, this project proposes structural and molecular modeling studies for natural and synthetic substances involved in important neglected diseases, such as Chagas' disease and leishmaniasis. The main objective of this study i…
This project considers the identification, biological evaluation and design of new ligands for the peroxisome proliferator-activated receptor delta (PPAR-delta), biological target involved in the several metabolic processes. For this study, advanced computational methodologies employed in the discovery and design process of potential agonists and/or antagonists of biological targets will …
Given the advancements in computational approaches and their role in healthcare - notably during the COVID-19 pandemic and in the interdisciplinary work of collaborative groups - a comparative analysis of computational (in silico) techniques and improvements in their respective implementations is timely, supporting the search for more effective and safer treatments for viral infectious di…
The presence of emerging pollutants in aquatic environments is a critical challenge to sustainability and public health. Substances such as levofloxacin, sulfamethoxazole, and nimesulide are widely used in medicine and exhibit high environmental persistence due to their low metabolization rates. These compounds can contribute to bacterial resistance development and negatively impact aquat…
Osteoarthritis (OA) is an inflammatory disease that affects the joints, causing pain and obstructing movement. It is remarkable that one of the sequels of this condition, chronic pain, is fairly difficult to treat, since the medications usually prescribed do not result in a significant improvement of the patient's condition and present dangerous side-effects. Taking into account that the …
Although there are inhibitors of 5-alpha-reductases activity in the drug market, the search for other compounds with the same attribute is still constant, in particular in the fields of study based on the potentiation of the inhibitory effect for these enzymes. The main focuses of these possible drugs refer to the anti-baldness treatments currently available for the genetic type of this p…
The quest for bioactive substances against targets on SARS-CoV-2 could aid potential antivirals for COVID-19. Among the strategies, receptor-binding domain (RBD) inhibitors on the viral Spike (S) could block its recognition by angiotensin-converting enzyme type II (ACE2) in cells. Such strategy in the onset of infection is relevant, because even though vaccines are under development and d…
Currently, Brazil is among the largest pesticide users in the world, reaching about 500,000 tons of pesticides per year. Consequently, this ends up impacting the health of the Brazilian population and the environment. Most pesticides end up acting mainly as endocrine disruptors, meaning that these substances can act as mimics or inhibitors of hormones. Thus, an endocrine disruptor can con…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 10 | Completed scholarships in Brazil |
| 19 / 17 | All research grants and scholarships |
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