CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Universidade Estadual de Campinas (1987), master's at Neurociências from Mcgill University (1993) and ph.d. at Neurociências from Mcgill University (1999). Has experience in Genetics, focusing on Human and Medical Genetics (Source: Lattes Curriculum)
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The central biological questions of our RIDC is the investigation of basic mechanisms that lead to epilepsy and stroke and the injury mechanisms that follow the disease onset and progression, and are related to prevention, treatment and rehabilitation. Our goals are to develop new methods and techniques to improve the understanding of mechanisms of damage, plasticity and repair in epileps…
Focal Cortical Dysplasia (FCD) represents the most prevalent cause of severe drug-resistant epilepsy in children. Despite the considerable progress in FCD diagnosis and surgical therapy, treatment of these patients remains a challenge. Our goal is to establish a human in vitro model of FCD using cortical organoids to recapitulate brain somatic mosaicism in FCD and to have a reliable model…
Focal cortical dysplasia (FCD) is a malformation of cortical development and its main clinical manifestation is intractable epilepsy. Despite the considerable progress in diagnosis and surgical therapy, treatment of these patients remains a challenge mainly due to surgical inaccessibility in eloquent cortex areas and the absence of etiology-specific anti-epileptic-drugs (AED). Furthermore…
Epilepsy affects about 1% to 2% of world population, and the mesial temporal lobe epilepsy (TLE) the most frequent, representing 40% of patients, these are often refractory to medicaI treatment. One of the most used tools to try to understand the pathophysiology of MTLE is induced animal models. Despite several animal models currently available and widely studied, most of these lesions pr…
(Only some records are available in English at this moment)
The data generated by the CEPID-BRAINN is multimodal, including omics, environmental, and clinical information. By processing and analyzing this data, we identified several mutations in patients with diverse clinical presentations of epilepsy. Many of these mutations occur in regions that express proteins. Therefore, our group aims to analyze and compare the behavior of mutant proteins wi…
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
Genetic ancestry has long been recognized as a key topic in population genetics. Knowing this, the genetic diversity of Latin American populations derives from the significant genetic contributions of Native American, European, and Sub-Saharan African populations. These historical events have resulted in the presence of heterogenous ancestral blocks in admixed populations. However, as the…
Epilepsy is a neurological disorder characterized by the permanent predisposition of the brain to generate spontaneous epileptic seizures. Mesial temporal lobe epilepsy (MTLE) is the most frequent form of focal epilepsy in adults, and hippocampal sclerosis (HS) is a common histopathological feature present in patients with MTLE. Genome-wide association studies (GWAS) have been widely used…
Autoantibody-mediated forms of encephalitis (AE) include neurological disorders characterized by subacute memory loss, movement disorders, and frequent, focal epileptic seizures. Objective: In this study, we aim to correlate phenotypes, immunological and genetic markers in our Brazilian patients with presumed AE. Methods: The cerebrospinal fluid (CSF), serum, and DNA samples of 50 patient…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 16 / 7 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 80 / 39 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 113 / 63 | All research grants and scholarships |
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