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Modeling mosaicism in focal cortical dysplasia using cortical organoids

Abstract

Focal Cortical Dysplasia (FCD) represents the most prevalent cause of severe drug-resistant epilepsy in children. Despite the considerable progress in FCD diagnosis and surgical therapy, treatment of these patients remains a challenge. Our goal is to establish a human in vitro model of FCD using cortical organoids to recapitulate brain somatic mosaicism in FCD and to have a reliable model, mimicking as much as possible the background genetic finding in the FCD patients, to screen novel anti-epileptic drugs. (AU)