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Modeling mosaicism in focal cortical dysplasia using cortical organoids

Grant number: 19/09090-9
Support type:Regular Research Grants
Duration: September 01, 2019 - August 31, 2021
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: University of California San Diego
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Iscia Teresinha Lopes Cendes
Grantee:Iscia Teresinha Lopes Cendes
Principal investigator abroad: Alysson Renato Muotri
Institution abroad: Sanford Consortium for Regenerative Medicine, United States
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Partner institutions: University of California, San Diego
Assoc. researchers:Andre Schwambach Vieira ; Fábio Rogério ; Simoni Helena Avansini
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

Focal Cortical Dysplasia (FCD) represents the most prevalent cause of severe drug-resistant epilepsy in children. Despite the considerable progress in FCD diagnosis and surgical therapy, treatment of these patients remains a challenge. Our goal is to establish a human in vitro model of FCD using cortical organoids to recapitulate brain somatic mosaicism in FCD and to have a reliable model, mimicking as much as possible the background genetic finding in the FCD patients, to screen novel anti-epileptic drugs. (AU)