Advanced search
Start date

Voxel-based diffusion tensor imaging in patients with focal epilepsies: comparative analyses of microstructural damage and anatomical connectivity between benign and refractory mesial temporal lobe epilepsy and frontal lobe epilepsy

Grant number: 16/05985-3
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2016
Effective date (End): July 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Fernando Cendes
Grantee:Hebel Oziel Urquia Osorio
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID
Associated scholarship(s):19/15161-6 - Regional analyses of the diffusion tensor imaging in the superficial white matter in patients with epilepsy due to focal cortical dysplasia, BE.EP.DD


DTI is an MRI technique based on the directional movement of water. It creates a virtual, in vivo, noninvasive three-dimensional representation of the white matter fiber tracts by analyzing the preferred direction of water given by the diffusion tensor in each image voxel (volumetric pixel). The diffusion tensor is a mathematical description of the magnitude (mean diffusivity-MD) and directionality (anisotropy) of the movement of water molecules. In the white matter, the presence of microstructures, such as myelin, limits the random Brownian movement of water molecules restricting the real diffusion of water.Studies on Mesial Temporal Lobe Epilepsy (MTLE) and Hippocampal Sclerosis (HS) analyzing DTI changes showed reduced FA and increased MD in the limbic system and ipsilateral temporal lobe of these patients. Whether these findings correspond to a cause (such as a developmental malformation possibly underlying the epileptogenic process) or a consequence (such as structural modification induced by seizures) of MTLE and HS is still debated. In addition, few studies have investigated DTI changes in frontal lobe epilepsy (FLE) associated with focal cortical dysplasia. Our objective is to analyze DTI images in patients with benign MTLE with and without HS compared to patients with refractory MTLE, FLE with focal cortical dysplasia and normal controls. We hope that through the comparative analyses of microstructural damage and anatomical connectivity between benign and refractory mesial temporal lobe epilepsy and frontal lobe epilepsy we will be able to clarify the pathophysiological correlations of DTI changes in MTLE and FLE, as well as different anatomical connectivity changes according to severity, hemispheric lateralization of the epileptogenic focus as well as the presence and type of MRI lesions. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
URQUIA-OSORIO, HEBEL; PIMENTEL-SILVA, LUCIANA R.; REZENDE, THIAGO JUNQUEIRA RIBEIRO; ALMENDARES-BONILLA, EIMY; YASUDA, CLARISSA L.; CONCHA, LUIS; CENDES, FERNANDO. Superficial and deep white matter diffusion abnormalities in focal epilepsies. Epilepsia, v. N/A, p. 13-pg., . (16/05985-3, 13/21056-4, 13/07559-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

Please report errors in scientific publications list using this form.