CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduation at Pharmacy from Universidade Metodista de Piracicaba (1990), master's at Pharmacology from Universidade Estadual de Campinas (1993) and Ph.D at Physiology from Universidade Estadual de Campinas (UNICAMP) (1998). Has experience in Pharmacology and toxicology. (Source: Lattes Curriculum)
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The aim of this project is to evaluate the efficacy of palladium-oxime complexes in targeting specific cellular organelles, such as lysosomes and mitochondria, to overcome drug resistance in bone tumors, particularly osteosarcomas. These tumors exhibit significant resistance to traditional drugs like cisplatin, doxorubicin, and methotrexate, presenting a major challenge in oncological tre…
Human-induced pluripotent stem cells (iPS) are an unlimited source of cells with pluripotent potential similar to embryonic stem cells, but generated from somatic cells. In vitro studies of disease modeling with these cells have stood out in drug screening, as they represent human diseases much better than the animal model. Thus, using myogenic progenitors and myotubes obtained from iPS c…
Although autophagy is well known as a physiological process in which the cellular components are degraded by lysosomes, current studies indicate that autophagy can also suppress or increase survival of tumor cells. In leukemia's, autophagy is generally unregulated. In addition, via GSK3, which seems to have a direct relationship with autophagy has been implicated as an important modulator…
Ageing is the primary risk factor for most neurodegenerative diseases as Parkinson disease (PD). Several individuals affected by this disease receive palliative treatment that helps to control clinical manifestation, however, without inhibiting disease progression. Cannabidiol (CBD) has been studied on PD research, due to its effect on the central nervous system and for showing neuroprote…
Data in the literature demonstrate that autophagy is involved in the muscle proteolysis process. Recent work carried out by our group in collaboration with the University of Minnesota (under study) has really demonstrated a central role of autophagy in the maturation process of muscle cells obtained from induced pluripotent stem cells. This data is of particular importance, since the proc…
The treatment used in acute myelogenous leukemia (AML) therapy involves the combination of cytarabine / idarubicin or daunorubinin. This treatment achieves a cure rate of 35-40% in patients less than 60 years of age, and 5-15% in older patients, since many individuals recur in a short time, which often results in low cure percentages. In this context, research involving strategies to impr…
Data in the literature demonstrate that autophagy is involved in the muscle proteolysis process. Recent work carried out by our group in collaboration with the University of Minnesota has really demonstrated a central role of autophagy in the process of muscle cell maturation obtained from induced pluripotent stem cells. This data is of particular importance, since the process of muscle m…
Induced Pluripotent Stem (iPS) cells emerge as a great promise for therapy in various diseases, such as ischemic heart failure, Parkinson's, Alzheimer's and Huntington's diseases, diabetes mellitus, sickle cell anemia, muscular dystrophy, among others. iPS are an unlimited source of cells with pluripotent potential, similar to those of embryonic stem cell (ESC), but with the advantage of …
| 1 / 1 | Ongoing grants |
| 6 / 2 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 16 / 8 | All research grants and scholarships |
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