bachelor's at Bacharelado Em Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1986), master's at Physiology from Universidade de São Paulo (1993) and doctorate at Biochemistry from Universidade Estadual de Campinas (1999). Has experience in Physiology, acting on the following subjects: células b, dexametasona, secreção de insulina, insulina-secreção and desnutrição. (Source: Lattes Curriculum)
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Diabetes mellitus (DM) is a metabolic disorder that affects 5% of people around the world. Currently, many drugs are used to treat diabetes, including exogenous insulin and allopathic drugs such as biguanidas, sulfonilureias and alpha-glycosidases inhibitors. However, they have many adverse side effects that diminish the quality of life of the patient and the answer for prolonged use. In …
Cachexia, a syndrome that commonly affects patients with malignant neoplasm, is characterized by a severe imbalance in metabolic homeostasis, and, especially, on the mechanisms involved in glycemic homeostasis. In previous studies, we have shown that cachectic solid Ehrlich tumor-bearing mice (TSE) exhibited decreased insulin secretion as well as increased peripheral sensitivity to this h…
(Only some records are available in English at this moment)
Cancer is a high incidence worldwide disease. Cachexia, a multifactorial metabolic syndrome that affects at least 50% of patients, leads to a progressive functional impairment, contributing significantly to a worse quality of life and high mortality. The solid Ehrlich carcinoma is a transplantable tumor model which leads to the development of the cachectic syndrome. The use of medicinal p…
Diabetes Mellitus (DM) is known as a metabolic disease which affect 5% of people in the world. Characterized by fasting hyperglycemia (equal or higher than 126 mg/dL), involving alteration on carbohidrate, lipids and protein metabolism. Every year the number of diabetic people increases significatly, and also the research involving medicinal plants with properties hypoglycemic used by tra…
Cachexia is a common syndrome that affects malignant tumor-bearing patients, and is characterized by a severe imbalance in metabolic homeostasis, acting especially in glycemic homeostatic mechanisms. In previous studies, we demonstrate that solid Ehrlich tumor bearing mice (SET) showed diminished insulin secretion and higher insulin sensitivity when compared to control group. Furthermore,…
(Only some records are available in English at this moment)
Type 1 diabetes (T1D) is a severe chronic disease of childhood and adolescence resulting from an autoimmune destruction of the pancreatic beta-cells. Endoplasmic reticulum (ER) stress contributes to beta-cell dysfunction and death in type 1 diabetes. CHOP is an important pro-apoptotic transcription factor induced by ER stress. Dr. Cardozo's group have previously shown that pro-inflammator…
In previous study we showed cachexia establishment in solid Ehrlich carcinoma bearing (SET) mice from the tenth day of tumor inoculation which is associated with a severe decrease in insulin secretory capacity. This profile led us to evaluate the inflammatory condition of pancreatic islets in SET mice. The results showed that tumor bearing mice had increased protein expression of pro-infl…
| 7 / 5 | Completed research grants |
| 23 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 32 / 16 | All research grants and scholarships |
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CV Lattes
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