CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduated at Veterinary Medicine at the University of São Paulo (1994) and completed her Ph.D. in Biochemistry/Immunology at the Federal University of Minas Gerais (1998) with a period as visiting student at the Department of Biochemistry of the University of Dundee (Scotland, 1997-1998). Has experience in Immunology, focusing on Celular Immunology. She is currently an Associate Professor of Immunology at the University of São Paulo (2001). She was an associate scientist at Howard Hughes Medical Institutes/Yale University (EUA), and a post-doctoral fellow at the Marine Biological Laboratory (USA), the National Institutes of Health (USA), and the Universität Würzburg (Germany). She was a visiting professor of Immunology at the University of Uppsala (Sweden, 2009). She organised the Marine Biological Laboratory (USA), Institute of Biomedical Sciences, and FAPESP Joint Courses (2012). (Source: Lattes Curriculum)
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Neutralization of a pathogen requires optimal affinity between the specific antibody and the pathogen. Such affinity is determined by the aminoacids landscape (charges and shapes) that form the contact regions. A pathogen can evade the host's immune system by changing its aminoacids, while the immunoglobulin repertoire of the host holds strategies for inducing high rates of mutation in it…
During terminal differentiation of B lymphocytes into plasma cells, large amounts of nascent immunoglobulins are translated and translocated into the Endoplasmic Reticulum (ER). Many immunoglobulins are not folded properly, and along with differentiation signals, activate an intracellular pathway named Unfolded Protein Response (UPR). The UPR aims at resolving the ER stress by promoting e…
(Only some records are available in English at this moment)
During terminal differentiation of B lymphocytes into plasma cells, the latter cells demand for increased levels of immunoglobulin synthesis. To accommodate the immunoglobulin overload, an expansion of the endoplasmic reticulum (ER) occurs. This causes stress in the ER, activating an intracellular signaling pathway named Unfolded Protein Response (UPR), pathway of which BiP is part of it.…
| 14 / 8 | Completed research grants |
| 10 / 3 | Completed scholarships in Brazil |
| 24 / 11 | All research grants and scholarships |
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