CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Chemistry from São Paulo University in 1995, he received his master's degree in Biological Sciences (Molecular Biology) with emphasis in Immunology from Federal University of São Paulo and Heart Institute (UNIFESP/InCOR-FMUSP) in 1999 and his doctoral degree in Biological Sciences (Molecular Biology) with emphasis in Immunology from Federal University of São Paulo and Heart Institute (UNIFESP/InCOR-FMUSP) in 2004. He moved to Boston in 2005 where he developed his postdoctoral studies applying phosphoproteomics in the analysis of the defect in central tolerance induction in non-obese diabetogenic mice at the Benoist-Mathis lab at the Joslin Diabetes Center, Harvard Medical School and at the Forest White lab at the Massachusetts Institute of Technology completing his studies in 2010. Soon after, he moved to London where he started a new postdoctoral study at The Institute of Cancer Research working with cancer cell phosphoproteomics analysis completing his study in 2012. Later, he moved to Brazil where he has been a Senior Research Scientist at the Laboratory of Applied Toxinology (LETA) at the Instituto Butantan in São Paulo leading the Proteomics and Mass Spectrometry Laboratory since June of 2013, professor at the Toxinology Post-graduate Program at the Butantan Institute since 2017 and accredited professor at the Biotechnology Inter-unity USP-IB-IPT program since May of 2019. He has applied his Biochemistry and Immunology background and expertise in Mass Spectrometry to analyze the potential anti-tumorigenic effect of proteins derived from the snake and scorpion venoms on different cancer cell lines and the peripheral effect of snake venom on different mouse tissues. (Source: Lattes Curriculum)
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Snake venom is a complex mixture of bioactive molecules with diverse biological activities, including anticancer properties. Despite the growing interest in its therapeutic applications, the molecular mechanisms underlying its cellular effects remain poorly understood. Advances in mass spectrometry-based proteomics have enabled the identification of key molecular targets, paving the way f…
Toxic substances and secretions of animals such as snakes, spiders and scorpions have been used in traditional medicine for the treatment of several diseases. Despite the inherent difficulty and high economic risk in the discovery and development of new drugs from natural products, the development and rapid advances of technologies such as mass spectrometry-based proteome analysis has all…
Oligopeptidases were first described as kininases from rabbit brain in the early 70's by Prof. Antonio C. M. Camargo at USP Ribeirão Preto Medical School. Studies from our research group suggested that more than 90% of thimet oligopeptidase (EC3.4.24.15; EP24.15) and neurolysin (EC3.4.24.16; Nln) are concentrated inside the cells; these data suggested some doubts about the major function …
Among the snakes distributed in Brazil, the genus Crotalus is the most lethal and the second most responsible for cases of ophidic accidents. Crotalus venom is known to be neurotoxic and cardiotoxic, in addition to affecting organs such as the lung and kidney of individuals bitten by the snake. Although there are several works in the literature with clinical, biochemical and physiological…
(Only some records are available in English at this moment)
Snake venom metalloproteases and disintegrins (SVMPs) are a class of proteins from snake venom presenting several biological functions such as inhibition of platelet aggregation and integrin-dependent cell adhesion by binding to collagen and integrin through different and independent motifs. Similarly to integrins, Discoidin Domain Receptors (DDRs) are known to bind and be activated by co…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 8 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 11 | All research grants and scholarships |
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