Alicia Juliana Kowaltowski
CV Lattes
Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Alicia Juliana Kowaltowski in research grants and scholarships supported by FAPESP.
- Young Scientist Program, AO.R
- Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism, AP.TEM
Abstract
Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/o...
- Acquisition of a jacketed autoclave for the production and experimentation animal facility of the University of São Paulo School of Pharmaceutical Sciences and Institute of Chemistry, AP.EMU
Abstract
The Production and Experimentation Animal Facility of the USP School of Pharmaceutical Sciences and Institute of Chemistry is a large multi-user facility that breeds and houses experimental animals for these two major branches of the University. Because of the growing demand for experimental animals of different lineages and for the use of animal housing systems with better environment...
(Only some records are available in English at this moment)
- Serum factors involved in beta-cell protection against Glucolipotoxicity, BP.PD
Abstract
We recently demonstrated that sera from lean calorically-restricted rats can protect beta cells, increasing glucose-sensitive insulin release under both normal culture conditions and glucolipotoxicity. The identification of molecular factors in the sera from lean animals that mediate this protective effect is of interest, since this could be a new therapeutic approach in the treatment o...
- Effects of caloric restriction on mitochondrial Ca2+ transport in cardiac and skeletal muscles, BP.DD
Abstract
We recently found that obese, ad libitum fed, rats and mice present lower mitochondrial Ca2+ uptake capacity in both the brain and liver when compared to lean, calorically-restricted animals. This was the first evidence that a dietary intervention can change mitochondrial Ca2+ transport properties. Ca2+ is a central metabolic regulator and, thus, diet-induced changes in mitochondrial Ca...
- Evaluation of NCLX and MCU functions in the central nervous system, BP.IC
Abstract
The central nervous system (CNS) has constant high energy demands to perform a series of specialized processes. Therefore it strongly relies on cellular respiration to supply that energy. Given that, in eukaryotic cells, mitochondria are the main source for ATP production, its importance in CNS cells becomes evident. Another relevant mitochondrial function is cytosolic Ca2+ uptake, as t...
(Only some records are available in English at this moment)
- Hepatic bioenergetics and redox signaling in obesity murine model: integrative analysis of nutritional, hormonal, and inflammatory stimuli, BP.DD
Abstract
Increased production of intracellular oxidants due to nutrient overloading from diet has been linked to the development of metabolic diseases such as Nonalcoholic Fatty Liver Disease (NAFLD) and diabetes type 2. The inability of the adipose tissue to handle excess lipids can result in increased efflux of Non-Esterified Fatty Acids (NEFAs) and release of proinflammatory cytokines and adi...
- Mitochondrial partitioning in mammalian cells, BP.PD
Abstract
Mitochondria are essential for energy metabolism in mammals. Although they are present in virtually all eukaryotic cells, very little is known about mitochondrial segregation during mitosis in mammals. Indeed, this process was long believed to be stochastic. Nonetheless, recent findings in yeast demonstrate that, when these cells are undergoing asymmetric cell division, mitochondrial so...
- Study of the metabolic reprograming sustaining microglial activation to inflammatory profiles, BP.PD
Abstract
Microglia are innate immune cells resident in the central nervous system, whose activation has been related to chronic pathologies such as Parkinson's disease and obesity. Recent evidences suggest that microglial activation is supported by decreases in oxidative metabolism a long with enhancements in anaerobic glycolysis. Nonetheless, the metabolic reprograming sustaining microglial inf...
(Only some records are available in English at this moment)
- Bioenergetic characterization of epidermal and dermal white adipose tissue progenitors in calorically-restricted mice: dissecting the role of mitochondrial metabolism in stem cell commitment and terminal differentiation, BE.EP.PD
Abstract
Understanding how mitochondrial metabolism impacts stem cell fate and homeostasis is a new field with promising results for both basic biology and cell therapy. In previous work, we described significant phenotypical alterations in the skin of calorically-restricted mice, especially in the epidermal and dermal adipose tissue, highly dynamic tissues maintained by stem cell pools. These a...
- Mitochondrial dynamics and Ca2+ uptake: bioenergetic implications, BE.PQ
Abstract
A wealth of evidence supports a link between nutritional status, mitochondrial morphology and dynamics, Ca2+ signaling and bioenergetic efficiency. However, a specific and central point that has not been studied yet is if changes in mitochondrial morphology, alone, promote changes in mitochondrial Ca2+ uptake and intracellular Ca2+ signaling. The aim of this project is to uncover the ef...
- Effects of lipids on insulin signaling in hepatocytes: impacts on mitochondrial ROS and nitric oxide generation, BE.EP.IC
Abstract
The increase in intracellular oxidant production due to nutrient load obtained in the diet has been directly linked to the development of metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Mitochondria are important sources in the generation of oxidants; the energy imbalance generated by increased caloric intake without the consideration of physiolo...
(Only some records are available in English at this moment)
*Updated June 15, 2019
| 14 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 34 / 11 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 57 / 28 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 35 |
| Citations | 313 |
| Cit./Article | 8.9 |
| Data from Web of Science | |
ALSABEEH, NOUR; CHAUSSE, BRUNO; KAKIMOTO, PAMELA A.; KOWALTOWSKI, ALICIA J.; SHIRIHAI, ORIAN. Cell culture models of fatty acid overload: Problems and solutions. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1863, n. 2, p. 143-151, FEB 2018. Web of Science Citations: 6. (13/07937-8, 15/07670-7, 15/25862-0)
ABREU, PHABLO. Bioenergetics mechanisms regulating muscle stem cell self-renewal commitment and function. BIOMEDICINE & PHARMACOTHERAPY, v. 103, p. 463-472, JUL 2018. Web of Science Citations: 0. (16/18633-8, 13/07937-8)
ROUBICEK, DEBORAH A.; DE SOUZA-PINTO, NADJA C.. Mitochondria and mitochondrial DNA as relevant targets for environmental contaminants. Toxicology, v. 391, p. 100-108, NOV 1 2017. Web of Science Citations: 17. (13/07937-8, 10/51906-1)
LUEVANO-MARTINEZ, LUIS ALBERTO; KOWALTOWSKI, ALICIA J.. Topological characterization of the mitochondrial phospholipid scramblase 3. FEBS Letters, v. 591, n. 24, p. 4056-4066, DEC 2017. Web of Science Citations: 0. (16/12999-0, 13/07937-8, 13/04919-9)
MORI, MATEUS P.; COSTA, RUTE A. P.; SOLTYS, DANIELA T.; FREIRE, THIAGO DE S.; ROSSATO, FRANCO A.; AMIGO, IGNACIO; KOWALTOWSKI, ALICIA J.; VERCESI, ANBAL E.; DE SOUZA-PINTO, NADJA C.. Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress. SCIENTIFIC REPORTS, v. 7, MAR 13 2017. Web of Science Citations: 4. (12/11889-6, 13/07937-8, 11/50400-0, 08/57721-3, 10/51906-1, 08/57952-5, 06/59786-0)
CAMPOS, JULIANE C.; QUELICONI, BRUNO B.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; DOURADO, PAULO M. M.; ANDRES, ALLEN M.; JANNIG, PAULO R.; GOMES, KATIA M. S.; ZAMBELLI, VANESSA O.; ROCHA-RESENDE, CIBELE; et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. AUTOPHAGY, v. 13, n. 8, p. 1304-1317, 2017. Web of Science Citations: 12. (16/01633-5, 10/00028-4, 10/51906-1, 12/05765-2, 15/20783-5, 09/12349-2)
QUELICONI, BRUNO B.; KOWALTOWSKI, ALICIA J.; GOTTLIEB, ROBERTA A.. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy. PLoS One, v. 11, n. 12, DEC 14 2016. Web of Science Citations: 6. (13/07937-8, 13/07292-7, 10/51906-1)
AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, n. 20, p. 3421-3449, OCT 2016. Web of Science Citations: 10. (13/07937-8, 10/51906-1, 13/04919-9, 14/17270-3, 15/25776-7, 15/15526-3)
ABREU, PHABLO; DIOGENES MENDES, SAVIO VICTOR; CECCATTO, VANIA MARILANDE; HIRABARA, SANDRO MASSAO. Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents. Life Sciences, v. 170, p. 33-40, FEB 1 2017. Web of Science Citations: 11. (16/18633-8, 11/06815-0)
TEOFILO SATURI DE CARVALHO, ANA ELISA; BASSANEZE, VINICIUS; FORNI, MARIA FERNANDA; KEUSSEYAN, ALINE ALFONSO; KOWALTOWSKI, ALICIA JULIANA; KRIEGER, JOSE EDUARDO. Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism. SCIENTIFIC REPORTS, v. 7, NOV 13 2017. Web of Science Citations: 3. (13/07937-8, 13/26440-7, 12/10109-7, 13/17368-0, 13/04871-6, 11/19678-1, 15/25776-7)
ASSIS-RIBAS, THAIS; FORNI, MARIA FERNANDA; BROCHADO WINNISCHOFER, SHEILA MARIA; SOGAYAR, MARI CLEIDE; TROMBETTA-LIMA, MARINA. Extracellular matrix dynamics during mesenchymal stem cells differentiation. Developmental Biology, v. 437, n. 2, p. 63-74, MAY 15 2018. Web of Science Citations: 7. (16/22298-0, 16/18277-7, 15/25776-7, 16/05311-2, 15/26328-8)
GARCIA-NETO, WILSON; CABRERA-OREFICE, ALFREDO; URIBE-CARVAJAL, SALVADOR; KOWALTOWSKI, ALICIA J.; LUEVANO-MARTINEZ, LUIS ALBERTO. High Osmolarity Environments Activate the Mitochondrial Alternative Oxidase in Debaryomyces Hansenii. PLoS One, v. 12, n. 1, JAN 6 2017. Web of Science Citations: 2. (13/04919-9)
SARAVIA, L. P. H.; ANANDHAKUMAR, S.; PARUSSULO, A. L. A.; MATIAS, T. A.; CALDEIRA DA SILVA, C. C.; KOWALTOWSKI, A. J.; ARAKI, K.; BERTOTTI, M.. Development of a tetraphenylporphyrin cobalt (II) Modified glassy carbon electrode to monitor oxygen consumption in biological samples. Journal of Electroanalytical Chemistry, v. 775, p. 72-76, AUG 15 2016. Web of Science Citations: 5. (12/20676-6, 14/15215-5, 10/51906-1)
AMIGO, IGNACIO; MENEZES-FILHO, SERGIO LUIZ; LUEVANO-MARTINEZ, LUIS ALBERTO; CHAUSSE, BRUNO; KOWALTOWSKI, ALICIA J.. Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. AGING CELL, v. 16, n. 1, p. 73-81, FEB 2017. Web of Science Citations: 16. (12/51288-1, 10/51906-1)
FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, JAN 18 2019. Web of Science Citations: 1. (16/09611-0, 16/01633-5, 17/16540-5, 10/00028-4, 10/51906-1, 17/11142-1, 12/05765-2, 15/20783-5, 15/22814-5, 17/16694-2, 09/12349-2)
LUEVANO-MARTINEZ, LUIS ALBERTO; FORNI, MARIA FERNANDA; DOS SANTOS, VALQUIRIA TIAGO; SOUZA-PINTO, NADJA C.; KOWALTOWSKI, ALICIA J.. Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, v. 1847, n. 6-7, p. 587-598, JUN-JUL 2015. Web of Science Citations: 16. (10/51906-1, 13/04919-9, 13/07937-8, 13/04871-6, 10/18254-0)
LUEVANO-MARTINEZ, LUIS ALBERTO. The chimeric origin of the cardiolipin biosynthetic pathway in the Eukarya domain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, v. 1847, n. 6-7, p. 599-606, JUN-JUL 2015. Web of Science Citations: 1. (13/04919-9)
LUEVANO-MARTINEZ, LUIS ALBERTO; KOWALTOWSKI, ALICIA J.. Phosphatidylglycerol-derived phospholipids have a universal, domain-crossing role in stress responses. Archives of Biochemistry and Biophysics, v. 585, p. 90-97, NOV 1 2015. Web of Science Citations: 7. (13/07937-8, 13/04919-9)
RUAS, JULIANA S.; SIQUEIRA-SANTOS, EDILENE S.; AMIGO, IGNACIO; RODRIGUES-SILVA, ERIKA; KOWALTOWSKI, ALICIA J.; CASTILHO, ROGER F.. Underestimation of the Maximal Capacity of the Mitochondrial Electron Transport System in Oligomycin-Treated Cells. PLoS One, v. 11, n. 3, MAR 7 2016. Web of Science Citations: 9. (12/51288-1, 13/07937-8, 11/50400-0, 10/51906-1)
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; TRUDEAU, KYLE; SHIRIHAI, ORIAN; KOWALTOWSKI, ALICIA J.. Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells, v. 34, n. 3, p. 743-755, MAR 2016. Web of Science Citations: 33. (13/07937-8, 14/17270-3, 13/04871-6, 10/51906-1)
CHAUSSE, BRUNO; VIEIRA-LARA, MARCEL A.; SANCHEZ, ANGELICA B.; MEDEIROS, MARISA H. G.; KOWALTOWSKI, ALICIA J.. Intermittent Fasting Results in Tissue-Specific Changes in Bioenergetics and Redox State. PLoS One, v. 10, n. 3, MAR 6 2015. Web of Science Citations: 16. (13/14203-0, 13/07937-8)
MUFTUOGLU, MELTEM; MORI, MATEUS P.; DE SOUZA-PINTO, NADJA C.. Formation and repair of oxidative damage in the mitochondrial DNA. MITOCHONDRION, v. 17, p. 164-181, JUL 2014. Web of Science Citations: 29. (10/51906-1)
KOWALTOWSKI, ALICIA J.; COSSO, RICARDO G.; CAMPOS, CLÁUDIA B.; FISKUM, GARY. Effect of Bcl-2 overexpression on mitochondrial structure and function. Journal of Biological Chemistry, v. 277, n. 45, p. 42802-42807, Nov. 2002.
CARREIRA, S. C.; FACUNDO, H. T. F.; KOWALTOWSKI, A. J.. Mitochondrial K+ transport and cardiac protection during ischemia/reperfusion. Brazilian Journal of Medical and Biological Research, v. 38, n. 3, p. 345-352, Mar. 2005.
KAKIMOTO, PAMELA A.; CHAUSSE, BRUNO; CALDEIRA DA SILVA, CAMILLE C.; DONATO JUNIOR, JOSE PRIME; KOWALTOWSKI, ALICIA J.. Resilient hepatic mitochondria! function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One, v. 14, n. 2, FEB 4 2019. Web of Science Citations: 0. (13/07937-8, 15/07670-7, 17/18972-0, 15/25862-0)
ABRANTES, ALINE B. DE P.; DIAS, GUSTAVO C.; SOUZA-PINTO, NADJA C.; BAPTISTA, MAURICIO S.. p53-Dependent and p53-Independent Responses of Cells Challenged by Photosensitization. Photochemistry and Photobiology, v. 95, n. 1, p. 355-363, JAN 2019. Web of Science Citations: 0. (13/07937-8, 12/50680-5, 17/04372-0, 14/18123-4, 10/51906-1)
SOLTYS, DANIELA TATHIANA; MARTINS PEREIRA, CAROLINA PARGA; ISHIBE, GABRIELA NAOMI; DE SOUZA-PINTO, NADJA CRISTHINA. Effects of post mortem interval and gender in DNA base excision repair activities in rat brains. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, v. 776, n. SI, p. 48-53, JUN 2015. Web of Science Citations: 3. (13/07937-8, 10/51906-1, 08/57721-3)
GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; RIBEIRO, MARCIO A. C.; CAMPOS, JULIANE C.; DOURADO, PAULO M.; KOWALTOWSKI, ALICIA J.; MOCHLY-ROSEN, DARIA; FERREIRA, JULIO C. B.. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 179, p. 129-138, JAN 20 2015. Web of Science Citations: 23. (13/07937-8, 12/05765-2, 10/51906-1)
MAGDALON, JULIANA; CHIMIN, PATRICIA; BELCHIOR, THIAGO; NEVES, RODRIGO X.; VIEIRA-LARA, MARCEL A.; ANDRADE, MAYNARA L.; FARIAS, TALITA S.; BOLSONI-LOPES, ANDRESSA; PASCHOAL, VIVIAN A.; YAMASHITA, ALEX S.; et al. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1861, n. 5, p. 430-438, MAY 2016. Web of Science Citations: 13. (12/25317-4, 10/51906-1, 13/14203-0, 15/19530-5, 09/15354-7, 11/03972-8)
FORNI, MARIA FERNANDA; PELOGGIA, JULIA; BRAGA, TARCIO T.; ORTEGA CHINCHILLA, JESUS EDUARDO; SHINOHARA, JORGE; NAVAS, CARLOS ARTURO; SARAIVA CAMARA, NIELS OLSEN; KOWALTOWSKI, ALICIA J.. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin. CELL REPORTS, v. 20, n. 11, p. 2678-2692, SEP 12 2017. Web of Science Citations: 3. (13/07937-8, 12/02270-2, 10/51906-1, 13/04871-6, 14/16320-7, 14/17270-3)
SANTOS, CARLA SANTANA; KOWALTOWSKI, ALICIA J.; BERTOTTI, MAURO. Single Cell Oxygen Mapping (SCOM) by Scanning Electrochemical Microscopy Uncovers Heterogeneous Intracellular Oxygen Consumption. SCIENTIFIC REPORTS, v. 7, SEP 12 2017. Web of Science Citations: 5. (13/07937-8, 14/22396-6, 10/51906-1)
KAKIMOTO, PAMELA A.; KOWALTOWSKI, ALICIA J.. Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance. REDOX BIOLOGY, v. 8, p. 216-225, AUG 2016. Web of Science Citations: 38. (13/03556-0, 13/07937-8, 10/51906-1)
CABRERA-OREFICE, ALFREDO; IBARRA-GARCIA-PADILLA, RODRIGO; MALDONADO-GUZMAN, ROCIO; GUERRERO-CASTILLO, SERGIO; LUEVANO-MARTINEZ, LUIS A.; PEREZ-VAZQUEZ, VICTORIANO; GUTIERREZ-AGUILAR, MANUEL; URIBE-CARVAJAL, SALVADOR. The Saccharomyces cerevisiae mitochondrial unselective channel behaves as a physiological uncoupling system regulated by Ca2+, Mg2+, phosphate and ATP. Journal of Bioenergetics and Biomembranes, v. 47, n. 6, p. 477-491, DEC 2015. Web of Science Citations: 3. (13/04919-9)
SILVA-PORTELA, RITA C. B.; CARVALHO, FABIOLA M.; PEREIRA, CAROLINA P. M.; DE SOUZA-PINTO, NADJA C.; MODESTI, MAURO; FUCHS, ROBERT P.; AGNEZ-LIMA, LUCYMARA F.. ExoMeg1: a new exonuclease from metagenomic library. SCIENTIFIC REPORTS, v. 6, JAN 27 2016. Web of Science Citations: 4. (08/57721-3, 10/51906-1)
FORNI, MARIA FERNANDA; CHAUSSE, BRUNO; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Bioenergetic profiling in the skin. EXPERIMENTAL DERMATOLOGY, v. 25, n. 2, p. 147-148, FEB 2016. Web of Science Citations: 4. (13/04871-6, 14/17270-3, 13/07937-8, 10/51906-1)
LUEVANO-MARTINEZ, LUIS ALBERTO; FORNI, MARIA FERNANDA; PELOGGIA, JULIA; WATANABE, II-SEI; KOWALTOWSKI, ALICIA J.. Calorie restriction promotes cardiolipin biosynthesis and distribution between mitochondrial membranes. MECHANISMS OF AGEING AND DEVELOPMENT, v. 162, p. 9-17, MAR 2017. Web of Science Citations: 6. (13/07937-8, 13/04871-6, 13/04919-9)
CHAUSSE, BRUNO; KAKIMOTO, PAMELA A.; CALDEIRA-DA-SILVA, CAMILLE C.; CHAVES-FILHO, ADRIANO B.; YOSHINAGA, MARCOS Y.; DA SILVA, RAILMARA PEREIRA; MIYAMOTO, SAYURI; KOWALTOWSKI, ALICIA J.. Distinct metabolic patterns during microglial remodeling by oleate and palmitate. BIOSCIENCE REPORTS, v. 39, n. 4, APR 30 2019. Web of Science Citations: 0. (13/07937-8, 15/07670-7, 15/21563-9, 15/25862-0)
USO DE DESACOPLADORES MITOCONDRIAIS PARA AUMENTO DE LONGEVIDADE ANIMAL PI0603151-0 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Alicia Juliana Kowaltowski; Camille Cristine Caldeira da Silva - July 2006, 17
USO DE SUBSTÂNCIAS AGONISTAS DE CANAIS DE K+ PARA PREVENIR OU TRATAR DANOS TECIDUAIS PROMOVIDOS POR ÁCIDO METIL-MALÔNICO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO SUBSTÂNCIAS AGONISTAS, COMPOSIÇÃO PARA O TRATAMENTO OU PREVENÇÃO DE DANOS TECIDUAIS, COMPOSIÇÃO COMPREENDENDO O USO DE SUBSTÂNCIAS AGONISTAS PARA USO NO TRATAMENTO OU PREVENÇÃO DE DANOS TECIDUAIS, BEM COMO COMPOSIÇÕES APRESENTÁVEIS EM QUAISQUER FORMAS FARMACÊUTICAS COMPREENDENDO SUBSTÂNCIA AGONISTA PARA USO NO TRATAMENTO OU PREVENÇÃO DE DANOS TECIDUAIS PI0204185-5 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Roger Frigério Castilho; Alicia Juliana Kowaltowski - September 2002, 24