MD from the State University of Campinas (1997), PhD in Medical Sciences from the State University of Campinas (1999) and post-doctoral studies at the Oregon Graduate Institute. Currently a professor at the Department of Biochemistry at the University of São Paulo, a member of the Academy of Sciences of the State of São Paulo and the Brazilian Academy of Sciences. Works in the area of energy metabolism. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Mitochondria are the hub of energy metabolism, organelles in which carbohydrate, amino acid and lipid metabolism are completed, and most cellular ATP is produced through oxidative phosphorylation. Because of the dependence on high inner mitochondrial membrane potentials in order to sustain oxidative phosphorylation, ion transport through the inner mitochondrial membrane must be carefully …
The study of redox processes has high potential to elucidate integrative mechanisms, due to the ubiquity and strength of their effects. Many studies involve the role of redox mechanisms in diseases. However, the complexity of this field has increased concerning structures, structure-function relations, methods, molecular and sub-cellular pathology of redox-regulated proteins, genomics, pr…
Changes in mitochondrial energy metabolism, ion transport, mtDNA metabolism and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and the toxicity of environmental contaminants. The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy and DNA metabolism and/or …
The Production and Experimentation Animal Facility of the USP School of Pharmaceutical Sciences and Institute of Chemistry is a large multi-user facility that breeds and houses experimental animals for these two major branches of the University. Because of the growing demand for experimental animals of different lineages and for the use of animal housing systems with better environmental…
(Only some records are available in English at this moment)
Mitochondrial Ca2+ has an important role in physiology and pathology. Mitochondrial transporters are crucial to maintain Ca2+ homeostasis, and Ca2+ efflux is controlled by the mitochondrial Na+/ Ca2+/ Li+ Exchanger (NCLX).NCLX is important to many physiological cellular processes, such as mitochondrial matrix redox state maintenence, and in different tissues, including brown adipose tissu…
Estradiol receptors (ERs) stimulation shows significant metabolic benefits after menopause. However, it is also related to an increased risk of hormone-dependent cancer and thrombosis. In this sense, the selective activation of the beta-type estradiol receptor (ER²) has shown antitumor action, besides the ability to modulate metabolic indicators of mitochondrial function. Surprisingly, to…
Ca2+ regulates several aspects of cell behavior, including mitochondrial function. Ca2+ activates several enzymes involved in the tricarboxylic acid cycle, as well as proteins involved in the transport of oxidable substrates. Physiological Ca2+concentrations lead to an increase in the rate of oxidative phosphorylation, and in the production rate of reactive oxygen species (ROS) under cert…
(Only some records are available in English at this moment)
The Brown Adipose Tissue (BAT) displays a central role in non-shivering thermogenesis and cold adaptation in mammals. To do such, potential energy generated in the mitochondria through oxidation of nutrients is dissipated in the form of heat by a specific uncoupling protein, UCP1. Recent data show that this process requires a fine tuning of fusion (union of two separated mitochondria) and…
Cells depend on an adaptable source of energy throughout different periods of the cell cycle. Regulation of energetic metabolism may therefore be related to the prevalence of proliferation or differentiation. Since mitochondria are a central structure in the production of ATP in eukaryotic cells, the importance of this organelle in cellular differentiation is evident. The balance between …
We recently demonstrated that sera from lean calorically-restricted rats can protect beta cells, increasing glucose-sensitive insulin release under both normal culture conditions and glucolipotoxicity. The identification of molecular factors in the sera from lean animals that mediate this protective effect is of interest, since this could be a new therapeutic approach in the treatment of …
(Only some records are available in English at this moment)
Mitochondrial metabolism and mTORC1 activity are central in nutrient sensing and coordinating an adaptive cellular response. In fact, both pathways are interconnected by different intermediates, providing reciprocal regulation. Given the well-established role of mitochondria in shaping intracellular calcium signals and the clear participation of calcium in mTORC1 regulation, it is rationa…
Brown Adipose Tissue (BAT) displays a central role in non-shivering thermogenesis and cold adaptation in mammals. To do such, potential energy generated in the mitochondria through oxidation of nutrients is dissipated in the form of heat by a specific uncoupling protein, UCP1. Recent data show that this process requires a fine tuning of fusion (union of two separated mitochondria) and fis…
Ca2+ is an ion of seminal importance not only in the context of excitotoxicity, but also physiologically, participating in many key processes in the central nervous system, including dendritic development, synaptogenesis, neurotransmitter release, and synaptic plasticity. Ca2+ ions can also act as a marker for activity regarding energetic demands, and are an important regulator of metabol…
Understanding how mitochondrial metabolism impacts stem cell fate and homeostasis is a new field with promising results for both basic biology and cell therapy. In previous work, we described significant phenotypical alterations in the skin of calorically-restricted mice, especially in the epidermal and dermal adipose tissue, highly dynamic tissues maintained by stem cell pools. These alt…
A wealth of evidence supports a link between nutritional status, mitochondrial morphology and dynamics, Ca2+ signaling and bioenergetic efficiency. However, a specific and central point that has not been studied yet is if changes in mitochondrial morphology, alone, promote changes in mitochondrial Ca2+ uptake and intracellular Ca2+ signaling. The aim of this project is to uncover the effe…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 40 / 17 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 70 / 41 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID