Dario Simões Zamboni

• Abstract

  COVID-19, caused by the new coronavirus (SARS-CoV-2) has become a worldwide health problem, with more than one million confirmed cases and 50,000 deaths by early April 2020. In its most severe forms, COVID-19 symptoms includes fever, cough, fatigue, headache and may progress to respiratory distress syndrome and death. The severe cases of COVID-19 are characterized by an intense inflammato…

  Inflammasome activation by SARS-CoV-2 and the role of this platform in the pathogenesis of COVID-19: a prospective study aiming NLRP3 inhibition for COVID-19 treatment, AP.R

• Abstract

  Differential recognition of pathogenic versus non-pathogenic microbes is essential to ensure rapid and effective immune responses that limit the replication of pathogenic microbes in cells and tissues. This differential recognition occurs through receptors located in the cytoplasm of innate immune cells. Among these receptors is a family of cytoplasmic proteins that contain NBD and LRR do…

  Mechanisms and consequences of the activation of cytoplasmic receptors by intracellular pathogens, AP.TEM

• Abstract

  Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…

  UK:Brazil Joint Centre Partnership in Leishmaniasis (JCPiL), AP.TEM

(Only some records are available in English at this moment)

• Abstract

  The inflammasome is a molecular platform found in the cytoplasm of eukaryotic cells, which activation leads to the processing of caspase-1 and cleavage of IL-1b and IL-18 into their active forms, as well as induction of inflammatory cell death through gasdermin-D activation. The receptor NLRC4, an essential cytosolic sensor for the activation of Naip/NLRC4 inflammasome is triggered by ba…

  Determination of the cell death role in leukocyte recruitment and control of Legionella pneumophila infection, BP.PD

• Abstract

  Inflammasome is a multiproteic complex that assists the activation of various inflammatory caspases in response to environmental signals or the entry of pathogens into a cell. Soon after the recognition of the ligand, the inflammasome complex is formed and promote the cleavage of pro-IL-1b, pro-IL-18 and gasdermin D. The activation of the inflammasome leads to cytokine secretion and infla…

  Optimization of a CRISPR/Cas9 genetic deletion system in macrophages to evaluate proteins important for the activation of NLRC4 inflammasome in macrophages, BP.MS

• Abstract

  COVID-19, caused by the new Coronavirus (SARS-CoV-2) has become a worldwide health problem, with more than one million confirmed cases and 50,000 deaths by early April 2020. In its most severe forms, COVID-19 symptoms includes fever, cough, fatigue, headache and may progress to respiratory distress syndrome and death. The severe cases of COVID-19 are characterized by an intense inflammato…

  Activation of inflammasome by SARS-CoV-2 and the role of this platform in the pathogenesis of COVID-19: a prospective study aimed at inhibiting NLRP3 for the treatment of COVID-19, BP.PD

(Only some records are available in English at this moment)