CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Ribeirão Preto Medical School, University of São Paulo (FMRP/USP). Participated in a Pre-Scientific Initiation program at the University of Brasília during high school (1991-1993) and graduated in Biological Sciences from the University of Brasília (1994-1997). Obtained a Ph.D. in Microbiology, Immunology, and Parasitology from the Paulista School of Medicine/Federal University of São Paulo (1998-2003), completed a Postdoctoral Fellowship in Microbial Pathogenicity at Yale University, USA (2003-2006), and earned the title of Associate Professor from the Ribeirão Preto Medical School/University of São Paulo (2011). Full member of the São Paulo State Academy of Sciences (ACIESP) and the Latin American Academy of Sciences (ACAL). CNPq Research Productivity Fellow, level A. Works in the fields of Immunology, Microbiology, Parasitology, and Cell Biology, with an emphasis on pathogen-host cell interaction and aspects of microbial pathogenicity and innate immunity. Published relevant articles that have significantly impacted the advancement of science. Mentored 21 master's students, 21 Ph.D. students, and dozens of undergraduate research students. Delivered over 180 scientific lectures, of which at least 40 were given abroad. Contributes significantly to the Brazilian scientific and educational system, collaborating with universities, scientific societies, and FAPESP, where a member of the scientific board since 2016, currently serving as the manager of the Biomedical Sciences area. (Source: Lattes Curriculum)
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This project aims to develop and optimize a mouse skin organoid system, creating an alternative to animal use in experimentation, in line with the principles of the 3Rs (reduction, refinement, and replacement). The use of organoids will allow multiple experiments to be conducted from a single animal, significantly reducing the use of mice. The goal is to create a skin organoid model that …
The research project "Innate Immune Mechanisms Mediated by Cytoplasmic Receptors in the Recognition and Control of Intracellular Pathogen Infections" aims to explore and elucidate the complex interactions between innate immune response mechanisms against intracellular pathogens, including Leishmania parasites, Legionella bacteria, and respiratory viruses such as coronavirus and influenza.…
Differential recognition of pathogenic versus non-pathogenic microbes is essential to ensure rapid and effective immune responses that limit the replication of pathogenic microbes in cells and tissues. This differential recognition occurs through receptors located in the cytoplasm of innate immune cells. Among these receptors is a family of cytoplasmic proteins that contain NBD and LRR do…
(Only some records are available in English at this moment)
Leishmaniasis are a group of diseases to pose a major public health problem worldwide, affecting mainly less favored individuals from emerging countries. The diseases are caused by protozoan parasites of the Leishmania spp genus, presenting different known clinical forms: cutaneous, mucocutaneous and visceral. In the mammalian host these parasites preferentially infect phagocytic cells, p…
COVID-19, caused by the new coronavirus (SARS-CoV-2) has become a worldwide health problem, with more than one million confirmed cases and 50,000 deaths by early April 2020. In its most severe forms, COVID-19 symptoms includes fever, cough, fatigue, headache and may progress to respiratory distress syndrome and death. The severe cases of COVID-19 are characterized by an intense inflammato…
Differential recognition of pathogenic versus non-pathogenic microbes is essential to ensure rapid and effective immune responses that limit the replication of pathogenic microbes in cells and tissues. This differential recognition occurs through receptors located in the cytoplasm of innate immune cells. Among these receptors is a family of cytoplasmic proteins that contain NBD and LRR do…
(Only some records are available in English at this moment)
The Gasdermin-D (GSDMD) protein, a member of the gasdermin family, is an essential protein during pyroptosis, a type of programmed cell death associated with the induction of inflammatory processes. It acts primarily by forming pores in the cell membrane, a process triggered as part of the innate immune response through the activation of pattern recognition receptors (PRRs), which detect …
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
Coxiella burnetii is a Gram-negative bacterium and causative agent of Q fever in humans. The bacterium is highly adapted to infect alveolar macrophages and subvert their functions, including the avoidance of TLR recognition, the inhibition of apoptosis and the modulation of diverse vesicle traffic pathways. Its virulence is dependent on the translocation of bacterial proteins (called effe…
The innate immune system is composed of several sensors and effectors widely expressed in macrophages, dendritic cells and epithelial cells. These molecules can rapidly induce inflammatory responses by triggering the production of cytokines, chemokines and release of danger signals present in the cytoplasm. In this context, host cell death has been reemerged as an important effector mecha…
Autophagy is a process of cellular degradation that captures and degrades organelles and intracellular pathogens and delivers them to autolysosomes for destruction. The role of autophagy in Trypanosoma cruzi infection is still largely unknown. During the development of the Ph.D. project, we found that autophagy is induced in response to T. cruzi favoring restriction of parasite replicatio…