CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
The research in my lab is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, hypoxia, etc.). These basic homeostatic regulations are orchestrated by the central nervous system that finely tunes pulmonary ventilation along with cardiac and vascular performance through the activity of the respiratory and autonomic outflows. The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure. (Source: Lattes Curriculum)
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This project aims to investigate the functional involvement of the olfactory bulb (MOB) and olfactory sensory neurons in ventilatory responses to hypercapnia. Evidence suggests that the MOB, in addition to displaying an oscillatory rhythm coherent with respiration, may modulate respiratory activity through its connections with nuclei involved in ventilatory control. In Protocol 1, we prop…
Breathing automatism and the chemical control of respiration are inseparable processes. The parafacial respiratory group (pFV) constitutes a group of excitatory neurons expressing the transcription factor Phox2b and plays a relevant role in the central chemoreception process (retrotrapezoid nucleus neurons - RTN) and respiratory automatism. The pFV is also regulated by afferent informatio…
Breathing automatism and the chemical control of respiration are inseparable processes. The parafacial respiratory group (pFV) constitutes a group of excitatory neurons expressing the transcription factor Phox2b and plays a relevant role in the central chemoreception process (retrotrapezoid nucleus neurons - RTN) and respiratory automatism. The pFV is also regulated by afferent informatio…
(Only some records are available in English at this moment)
Breathing automaticity and chemoreception are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO2 constant. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is present…
(Only some records are available in English at this moment)
The population aging emphasizes the need to study prevalent diseases in the elderly,such as Parkinson's Disease (PD), characterized by the progressive death of dopaminergicneurons in the Substantia Nigra. While movement-related symptoms are the most well-known,respiratory dysfunctions account for the majority of deaths associated with this disease. In thelaboratory, the PD model induced b…
The main physiological function of breathing is the maintenance of blood gases (CO2 and O2) homeostasis. For this fine tuning to take place, the Central Nervous System (CNS) must receive refined and accurate information. Among the neural clusters that control respiratory activity, the ventrolateral region of the brainstem, namely the retrotrapezoid nucleus (RTN) are capable of detecting i…
Inflammation is defined as a biological response caused by numerous agents and is a key element in defense against infections. In the central nervous system, the main defense cell is microglia. Because of the elementary source of inflammatory factors, regulation of microglia may represent the therapeutic potential for neuropsychiatric diseases and, when activated in the ventral respirator…
Ventilation is a physiological process that depends on the integration of neural networks, which is essential for maintaining the internal physiological balance. All this mechanism has the main objective to maintain adequate levels of O2 and CO2 in the blood and tissues. It is well established that central and peripheral chemoreceptors detect changes in arterial blood gas concentrations a…
The hypothalamus is a region involved in the functioning of several systems essential for the maintenance of life. A series of studies have demonstrated that hypothalamic regions, especially the paraventricular nucleus of the hypothalamus (PVH) project into fundamental regions of ventilatory control, such as the ventral respiratory column (VRC), the nucleus of the solitary tract (NTS) and…
(Only some records are available in English at this moment)
Guanylyl cyclase D positive (GCD+) neurons are a specialized set of olfactory sensory system. They are thought to play a key role in mediating innate odor preferences, learning and in the CO2 olfactory sensing. GCD+ neurons from olfactory epithelium project their axons to the necklace glomeruli, in the caudal olfactory bulb (OB). They also express other essential components in the CO2 olf…
The opioid epidemic claims more than 50,000 lives every year in North America and contributes to a significant drop in overall life expectancy worldwide. The primary cause of death associated with opioid-based analgesics and drugs of abuse is opioid-induced respiratory depression (OIRD). Although the mortality risk increases in a dose-dependent manner, opioid use is particularly dangerous…
Respiratory activity is maintained unconsciously by the activity of respiratory chemoreceptors, including those located in the retrotrapezoid nucleus (RTN), which control respiratory output in response to changes in tissue CO2/H+. Despite the importance of RTN chemoreceptors, we still do not know about the mechanisms that support their activity, particularly the neuromodulation involving …
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 14 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 26 / 19 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 56 / 47 | All research grants and scholarships |
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