CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Argentina
graduation at Licenciatura Em Ciências Químicas from Universidad de Buenos Aires (1996) and PhD at Universidad de Buenos Aires (2002). Until the end of march 2021 shewas associate professor at Universidade de São Paulo. Has experience in Chemistry, acting on the following subjects: diabetes, ilhotas pancreaticas, prolactin, cáncer de mama and insulin. (Source: Lattes Curriculum)
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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from deficiency in insulin secretion, action thereof, or both. Islet transplantation is a promising therapy for the treatment of type 1 diabetes mellitus (T1DM). However, the islet grafts are subjected to rejection by the immune system of the receptor patients. Thus, in order to optimize the success rate of…
One of the goals in the treatment for diabetes is to enhance pancreatic beta-cell function, proliferation and survival. Beta-cell apoptosis occurs in diabetes where genes of bcl-2 family members are known either promote or to inhibit it. Recent results from our group showed that recombinant human prolactin (rhPRL) inhibits beta-cell apoptosis. Using bidimensional gel electrophoresis, we r…
(Only some records are available in English at this moment)
Breast cancer is the second leading cause of cancer-related deaths among women in the world. Concentered efforts have been made in recent years to develop therapies that are able to treat various forms of breast cancer more effectively. Targeted therapy in breast cancer is dictated by the expression of specific molecules such as hormone or growth factor receptors. However, these agents ar…
Autophagy is a mechanism of recycling cytoplasmic components and is essential for cellular homeostasis. Under stress conditions, this mechanism is activated above basal levels, promoting the degradation of protein aggregates and defective organelles, thus avoiding cell damage that could compromise cell viability. Studies carried out by our group have shown not only that PRL promotes cytop…
One of the goals in the treatment of type 1 diabetes is to enhance pancreatic beta-cell function, proliferation and survival. Beta-cell apoptosis occurs in diabetes where genes of the bcl-2 familyare known to either promote or to inhibit it. Results from our lab have shown significant prolactin-induced cytoprotection against apoptosis in beta-cells after the different cell death inducing …
(Only some records are available in English at this moment)
Concentered efforts have been made in recent years to develop therapies that are able to treat various types of cancer more effectively. A promising alternative treatment is photodynamic therapy (PDT), consisting in tissue destruction by visible light in the presence of a photosensitizer substance and oxygen. Previous results from our group have shown that PDT using methylene blue as a ph…
Recent results from our lab have shown that in beta-cells, prolactin (PRL) leads to the upregulation of HSPB1, and that silencing its expression completely abolishes PRL's effect on cytoprotection. Moreover, by performing immunopreciptation flowed by mass spectrometry we now know that only when beta-cells were co-treated with cytokines and PRL, HSPB1 interacts with Superoxide Dismutase 1 …
| 7 / 6 | Completed research grants |
| 10 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 19 / 14 | All research grants and scholarships |
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