CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's degree in Biological Sciences from the University of São Paulo, master's and doctoral degrees in Immunology from the University of São Paulo (Sandwich program at the Pasteur Institute - France), and Postdoctoral studies at UMR8147, Necker Hospital - France. Advisor for Master's and Ph.D. students in the Postgraduate Program in Microbiology and Immunology - São Paulo School of Medicine, UNIFESP. Associate Professor - UNIFESP - Department of Microbiology, Immunology, and Parasitology. Research Focus: Study of the biology of invariant Natural Killer T (iNKT) cells, their application in immunotherapy, and the modulation of the immune system by the stress response. (Source: Lattes Curriculum)
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Animal experimentation plays a crucial role in advancing our understanding of human physiology and developing treatments for a wide range of diseases. Progress in this field relies heavily on high-quality, reproducible experiments and the application of advanced genetic manipulation tools, such as targeted gene deletion. In this context, the Center for the Development of Experimental Mode…
Classically, cells of the immune system are categorized into two large groups based on characteristics considered unique and exclusionary: innate cells, activated via pathogen-associated molecular pattern receptors (PAMPs) or tissue damage-associated molecular pattern receptors (DAMPs), and adaptive cells, which act through specific antigen receptors originating from post-somatic recombin…
Classically, cells of the immune system are categorized into two large groups based on characteristics considered unique and exclusionary: innate cells, activated via pathogen-associated molecular pattern receptors (PAMPs) or tissue damage-associated molecular pattern receptors (DAMPs), and adaptive cells, which act through specific antigen receptors originating from post-somatic recombin…
(Only some records are available in English at this moment)
Invariant Natural Killer T (iNKT) cell activation by ±-galactosylceramide (±GC) potentiates cytotoxic immune responses against tumors. However, ±GC-induced liver injury is a limiting factor for iNKT-based immunotherapy. Although adrenergic receptor stimulation is an important immunosuppressive signal that curbs tissue damage induced by inflammation, its effect on the antitumor activity of…
The gut lumen contains several microbial agents that are essential for digestion and so for nutrient supply. The local immune compartment is critical for shaping the gut microbiota and maintaining the intestinal barrier. The iNKTs influence both the microbiota profile and intestinal inflammation, whereas the IL-22-producing ILC3 cells are essential to control bacterial translocation from …
The liver is responsible for several vital functions, and due to its physiological and anatomical characteristics, it is a constant target of different injuries. In this context, the magnitude and duration of the inflammatory process associated with tissue damage directly impact liver physiology. Given the direct relationship between inflammation and the activation of the immune system, i…
(Only some records are available in English at this moment)
The liver has a relevant role on the physiological metabolism as well as in the process of systemic detoxification, and due to its physioanatomy, it is a constant target of distinct insults, potentially pathological, whose consequences rely on the interactions between hepatocytes and the different resident immune cells. In this context, invariant natural killer T cells (iNKT) have stood o…
Uma parte do projeto temático a tem como objetivo determinar de forma específica a influência do metabolismo celular e da sinalização de glicocorticoides e neurotransmissores sobre células do epitélio intestinal, hepatócitos e células imunes. Para tanto, serão estabelecidas linhagens de camundongos utilizando a tecnologia de cruzamentos Cre x loxp. Nos animais Cre, as células de interesse…
The antitumor efficiency of alpha-galactosylceramide (aGC)depends both on IFN-gamma production and on cytotoxic pathways such as FasL and NKG2D. Recent data from our group show that glucose metabolism is a critical process for IFN-gamma production by iNKT lymphocytes when stimulated with aGC. Therefore, it is reasonable to assume that in a glucose-deprived environment-commonly observed du…
Liver homeostasis, due to its anatomical structure, depends on the tolerance to microbiota derivatives and immunity to pathogens. In this sense, several studies highlighted the role of invariant T Natural Killer (iNKT) cells in the physiopathology of immune-mediated hepatic diseases. These cells constitute a group of non-conventional T lymphocytes with selectivity for glycolipids expresse…
Invariant Natura Killer T lymphocytes (iNKT) are immune cells that recognize lipid antigens compexed into CD1D molecules. Alpha-GalactosylCeramide (a-GalCer) is the most studied agonist, with main feature being the capacity to rapidly induce secretion of several cytokines. This ability to potentiate immune responses has been demonstrated in different clinical and experimental studies. Alt…
Despite the efforts of many research groups, one issue that still intrigues the scientific community are the mechanisms that control the evolution of neoplastic cells. This is drawing attention to the role of immune cells in the tumor microenvironment, especially innate immunity cells. Among them, macrophages play a controversial role. Some studies show that infiltrating macrophages can c…
(Only some records are available in English at this moment)
The focal and segmental glomerulosclerosis (FSGS) is a leading cause of chronic kidney disease and is associated with an increasing number of dialysis and transplantation. The allergic asthma is a chronic disease that is increasing worldwide in the last decades. Because of the high levels of mortality and morbidity both diseases are considered as a socioeconomic problem. This situation is…