Ricardo de Marco

• Abstract

  This Project has the objective of perform genomic analysis under a evolutive context related to two human diseases, diabetes miellitus type 2 and schistosomiasis. Diabetes is a group of metabolic diseases characterized by hyperglycemia derived from the defects in the secretion or action of insulin. Due to the high prevalence of diabetes type 2, it is argued that the majority of mutations …

  Evolution of genes associated with Diabetes type 2, AP.R

• Abstract

  This project has the objective to study Micro-Exon Genes and their protein products that are found in the host-parasite interface. We will perform experiments to understand the interaction of PCM (Proteins coded by MEGs) with human proteins and cells. Previous results obtained by our group demonstrated that PCMs are involved in erythrocyte hemolysis, as well as the interaction with protei…

  Study of micro-exon genes (MEGs) of the human parasite Schistosoma mansoni and of the interaction of their protein products with human cells, AP.R

• Abstract

  This project aims to study micro-exon genes (MEGs) and its protein products that are located at the host parasite interface. We wil perform the heterologous expression of the main isoforms of PCMs (protein coded by micro-exon) to characterize their biophysical properties and to perform assays aiming to understand the role of these proteins. Double-hybrid assays will be performed to searc…

  Study of micro-exon genes (MEGs) from the human parasite Schistosoma mansoni and its protein products, AP.R

(Only some records are available in English at this moment)

• Abstract

  The objective of this project is to analyze the distribution of the transposable element Sm1-alpha and evaluate its impact in the evolution of the Schistosoma mansoni genome.Transposable elements (transposons) have the capacity to replicate in their hosts genome and it has been demonstrated that they exert considerable influence in the evolution of genes and genomes. . The Sm1-alpha eleme…

  Distribution analysis of the transposable element SM1-alpha in the genome of the parasite Schistosoma mansoni, BP.IC

• Abstract

  This study aims to express and characterize the GTPase domain of septins from the trematode flatworm Schistosoma mansoni. This parasite is the etiologic agent of Schistosomiasis, a disease that affects about 210 million people in 74 countries. The septins are a conserved family of GTP-binding proteins, which were first associated with the process of cytokinesis in yeast budding. Today, it…

  Clonning, expression and structural studies of the GTPase domain from recombinat sseptins from Schistosoma mansoni, BP.IC

• Abstract

  The helminth Schistosoma mansoni is one of the causative agents of Schistosomiasis, a disease that affects 210 million people in 76 countries, only in Brazil are affected 6 million. It is believed that infection is successful due to modulation of the immune system through host of protein secreted by the parasite. Praziquantel is only one drug presently used for treatment of schistosomias…

  Structural Characterization of Proteins Coded by Genes of Micro-Exon (MEG) Schistosoma mansoni: MEG 5 and MEG 8.2., BP.MS

(Only some records are available in English at this moment)

• Abstract

  The project presented here aims to to study the correlation between gene order and expression in the genome of organims from Schistosoma genera, with special emphasis in Schistosoma mansoni. Although this question has been addressed by the host research group in other models, organisms of the Schistosoma genera display peculiarities, such as transitions between very different forms in its…

  Analysis of gene clusters of Shistosoma mansoni involved in parasite differentiation and infection of the host, BE.PQ