CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Instituto de Saúde e Sociedade (ISS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Physiotherapy from Universidade Metodista de Piracicaba (1998), Ph.D. in Science (Experimental Pathophysiology) from Universidade de São Paulo (2005) and post-doctorate in Pulmonary Pathophysiology at FMUSP (2008). In 2008, she joined as adjunct professor at the Federal University of São Paulo, Dept of Biological Sciences, Campus Diadema, where she worked until 2015. Now she is currently Associate Professor IV at the Dept of Biosciences, Institute of Health and Society, Baixada Santista Campus of the Federal University from São Paulo where she coordinates the Laboratory for Studies in Pulmonary Inflammation. She also works as a collaborating researcher at the Experimental Therapeutics Laboratory I of the Faculty of Medicine of the University of São Paulo. She has expertise in the field of pathophysiology and pulmonary histopathology, acting on the following topics: inflammatory mediators, experimental models of lung inflammation, bronchial asthma, pulmonary emphysema, acute lung injury, lung remodeling, anti-inflammatory cholinergic system and effects of phytochemical compounds in lung diseases. She was coordinator of the Graduate Program in Chemical Biology from 2012 to 2015. She is a collaborating advisor of the Medical Sciences Program in the area of #8203;#8203;inflammatory and allergic processes at the Faculty of Medicine of the University of São Paulo and permanent advisor in the Interdisciplinary Science Program of Unifesp Health, Baixada Santista Campus. (Source: Lattes Curriculum)
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SARS-CoV-2 (Severe Acute Respiratory Syndrome, Coronavirus 2) is the virus that causes COVID-19 (Coronavirus disease 2019), declared as a pandemic in March / 2020, which in its severe form leads to death due to acute lung injury (ALI), refractory hypoxemia and the presence of microthrombi. The virus enters the cell after binding the Spike protein to ACE2 (angiotensin-converting enzyme 2).…
According to DATASUS data, respiratory diseases, including asthma, emphysema, pneumonia, bronchitis and bronchiolitis, have led to more than 135,000 deaths in 2017. The acute respiratory distress syndrome (ARDS) affects 2% to 26% of all mechanical ventilation hospitalized in intensive care centers is characterized by a diffuse pulmonary inflammatory response that causes acute lung injury …
The anti-inflammatory cholinergic system (SCAI), described a few years ago, has been not fully investigated in the lung and may be an important therapeutic target for the treatment of pulmonary diseases. We recently demonstrated that animals with VAChT deficiency, the protein which transports acetylcholine (ACh), developed inflammation, activation of the NF-kB and reduction of JAK2-STAT3-…
(Only some records are available in English at this moment)
Chronic obstructive pulmonary disease (COPD) represents a serious challenge to global health, causing high mortality rates and imposing significant costs on the healthcare system. Unfortunately, the therapeutic options currently available are only palliative, focused on relieving symptoms. In this context, a promising study seeks to explore the benefits of treatment with the complexed ext…
The Acute Respiratory Distress Syndrome (ARDS) is defined as a severe lung diseasethat can lead to respiratory failure. Among the main causes is bacterial and/or viralpneumonia. The inflammatory process and cytokine storm is the mainpathophysiological characteristic and can compromise lung function and other organs.Several mechanisms and mediators are described as important in the pathoph…
Acute Respiratory Distress Syndrome (ARDS) is a severe lung disease that leads to respiratory failure, with several causes including bacterial and/or viral pneumonia. To fight the injury, the immune system is triggered to recruit defense cells, this inflammatory process, when exacerbated, damages the lung tissue and compromises its function of oxygenating the blood and removing carbon dio…
Acute lung injury (ALI) is characterized by acute lung insufficiency, a sudden onset, recruitment of polymorphonuclear leukocyte recruitment and the release of inflammatory mediators, and it can induce an increase in the cytokine levels, and it is one of the consequences of severe COVID-19. There is no effective treatment, and the mortality rates are high. The stimuli of cholinergic pathw…
(Only some records are available in English at this moment)
The Renin-Angiotensin System (RAS) plays a fundamental role in maintaining organism homeostasis. Its effect on inflammation, particularly pulmonary, has gained prominence in recent years. The angiotensin converse enzyme 2 (ACE2), highly expressed in lung cells, has an important role in balancing the pro- and anti-inflammatory effects induced by the AT1R and MasR receptors, respectively. W…
Acute lung injury (ALI) is characterized by sudden onset, polymorphonuclear cells recruitment and release of pro-inflammatory mediators, which can induce changes in cytokines. The reduction of vesicular transport of acetylcholine (VAChT), which is associated to reduction on the release of ACh, the main mediator of cholinergic anti-inflammatory system, modulates pulmonary inflammation. Nic…
| 6 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 22 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 31 / 22 | All research grants and scholarships |
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