She graduated in Biological Sciences (Licentiate and Bachelor's Degree) from the Federal University of Santa Catarina (1993-1997). She has a PhD in Science, with a Concentration Area in physiology, from the Federal University of São Carlos (2000-2004). She performed a doctoral 'sandwich' internship (2002) at the Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA, and a post-doctorate (2005-2006) at the Institute de la Santé et de la Recherche Médicale (INSERM, Unité 553) in Paris, France. The University of Nottingham, England, awarded her a Visiting Fellowship (2015). She is currently an Associate Professor at the Federal University of São Carlos. She coordinates the LABEN (Laboratory of Biology of Aging) in the Department of Gerontology at UFSCar. She leads the Biology of Aging research group registered in the CNPq directory of research groups. She advises on the Master's course in the Graduate Program in Gerontology (PPGGero / UFSCar), part of the REPRINTE (Network of Interdisciplinary Graduate Programs on Aging). She also advises on master's and Doctorate courses of the Interinstitutional Graduate Program in Physiological Sciences (UFSCar / UNESP). She is a reviewer for several periodicals in the field of Aging, Alzheimer's Disease, and Cancer and a scientific advisor to Brazilian (CNPq and FAPESP) and foreign funding agencies (Alzheimer's Association, FONDECYT-Chile, Czech Science Foundation-Czech Republic, United States-Israel Binational Science Foundation and The Netherlands Organization for Health Research and Development). She is a member of the New Course Proposal Evaluation Committee (APCN), of the CAPES quadrennial evaluation and of the CAPES Thesis Award in the Interdisciplinary area. She has projects in collaboration with several international institutions such as Trinity College Dublin - Ireland; University of Nottingham - UK; Università Degli Studi di Milano - Italy; Universitat de València and Universitat de Barcelona - Spain; Université du Quebec à Montréal - Canada, Olivia Newton-John Cancer Research Institute - Australia, University of California in Berkeley, Virginia Commonwealth University and Purdue University - USA. She is a member of the CIBFar (Center for Research and Innovation in Biodiversity and Pharmaceuticals), a program belonging to FAPESP's CEPID (Research, Innovation and Diffusion Centers). She has been selected as an Atlantic Fellow for Equity in Brain Health by the Global Brain Health Institute (GBHI) of Trinity College Dublin, Ireland (2021-2022). She has experience in Cell Biology and Biochemistry, with an emphasis on Molecular Biology, acting on the following topics: aging, the elderly, biomarkers for Alzheimer's disease, ADAMs, cancer, and mammalian cell culture. E-mail: mcominetti@ufscar.br / ORCID: https://orcid.org/0000-0001-6385-7392 (Source: Lattes Curriculum)
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Alzheimer's Disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by extensive neuronal losses and deposits of neurofibrillary tangles and senile plaques. Mild neurocognitive impairment (MCI) is characterized by cognitive decline, but with preservation of functionality, being an intermediate stage between normal AD cognition, but that can be reversed. ADAM10 is…
AD (Alzheimer's disease) is a progressive neurodegenerative disease predominantly characterized by cortical atrophy in the medial temporal lobe, and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam study in 1992, it is known that T2DM (type 2 diabetes mellitus) increases the risk of dementia. …
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is neurodegenerative, gradual, and progressive, characterized by cortical atrophy predominant in the medial temporal lobe, extensive neuronal losses, deposits of neurofibrillary tangles, and amyloid plaques. An intermediate stage between normal cognition and AD is mild cognitive impairment (MCI), which can be reversed. Knowledge about the pathophysiology of AD has…
Introduction: The significant increase in the elderly population, concomitant with the growth ofdementia rates, highlights the urgency of effective scientific dissemination actions aboutof these themes. The impact of this condition demands actions aimed at promotingawareness and awareness, aiming to eliminate stigmas and facilitate early diagnosis andhumanized. Therefore, making scientifi…
Introduction: The significant increase in the elderly population, concomitant with the growth ofdementia rates, highlights the urgency of effective scientific dissemination actions aboutof these themes. The impact of this condition demands actions aimed at promotingawareness and awareness, aiming to eliminate stigmas and facilitate early diagnosis andhumanized. Therefore, making scientifi…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is a gradual and progressive neurodegenerative disease characterized by predominant cortical atrophy of the medial temporal lobe and microscopically, by extensive neuronal losses and deposits called neurofibrillary tangles and senile plaques. Since the results of the Rotterdam studies in 1992, type 2 Diabetes mellitus (DM2) has been known to increase the risk of d…
Alzheimer's disease (AD) is a progressive and gradual neurodegenerative disease, whose main characteristic is cortical atrophy, predominant in the medial temporal lobe, in the hippocampus region and at the microscopic level there is evidence of severe neuronal losses, due to the accumulation of senile plaques and neurofibrillary tangles. The results obtained in the Rotterdam study showed …
Dementia caused by Alzheimer's disease (AD) is the most prevalent dementias in Brazil and in the world and several studies have associated the allele µ4 of the Apolipoprotein E (APOE) as the main genetic risk factor for AD at late onset. The evidence of its negative impact on cognitive functions has been demonstrated in different populations, which include healthy individuals from differe…
(Only some records are available in English at this moment)
A disintegrin and metalloprotease 10 (ADAM10), a transmembrane protein, has been investigated as an Alzheimer's disease (AD) blood-based biomarker. Under physiological conditions, it is the major constitutive ±-secretase responsible for the non-amyloidogenic cleavage of amyloid precursor protein (APP), preventing the generation of the amyloid beta peptide (AB). In AD, however, there is a …
The APOE4 allele (so-called µ4) is the strongest genetic risk for sporadic late-onset Alzheimer's disease (LOAD), and is associated with an increase in the levels of amyloid deposition and an early cognitive impairment. To understand the relation between APOE genotype and brain electrical activity, we developed a systematic review, which was recently submitted and is entitled "A systemati…
Cancer is a leading cause of death worldwide. Lung and breast cancer are the most frequent cancer types. In vitro screening methods for antitumor candidate compounds represent a rapid, simple, and reproducible approach to obtain essential data indicative of activity and interaction of new molecules with potential cell targets. In vitro assays based on two-dimensional (2D) monolayer cultur…
Alzheimer's disease (AD) is a neurodegenerative disorder that most affects the elderly population. Classical neuropathological hallmarks of AD include amyloid plaques and neurofibrillary tangles, containing aggregated ²-amyloid (A²) and hyperphosphorylated tau, respectively. In our laboratory, several studies were performed in the area of blood biomarkers for AD, especially focusing on AD…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 10 | Completed research grants |
| 11 / 11 | Ongoing scholarships in Brazil |
| 30 / 24 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 13 / 12 | Completed scholarships abroad |
| 72 / 60 | All research grants and scholarships |
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CV Lattes
ORCID