CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor Kleber Thiago de Oliveira has a degree in Chemistry from the University of São Paulo (bachelor -1998-2001- and licensed -2004-2005). He has a PhD in Science (2002-2006) with a focus on Synthetic Organic Chemistry, also obtained from the University of São Paulo (USP-RP). He has experience in Organic Synthesis and develops research on synthesizing photosensitizing molecules with applications in Photonic Therapies, Organic Synthesis methodologies, and Total Syntheses of Active Pharmaceutical Ingredients (IFAs). He also works on the development of reactions in a continuous flow regime, aiming to design and build new continuous flow reactors for API production. Reactions mediated by photocatalysis and electrosynthesis are the main focuses of the work developed by his group. He carried out post-doctorate at the University of Aveiro - Portugal (2006-2007), and the University of São Paulo (2007-2008) and served as a Visiting Professor at Florida State University - USA (2015), working with photocatalyzed reactions in Continuous Flow regime under the supervision of Prof. D.Tyler McQuade. He is currently a Full Professor at the Federal University of São Carlos (UFSCar) at CCET-UFSCar and the Head of the Chemistry Department at UFSCar. He is a member of the Brazilian Chemical Society. (Source: Lattes Curriculum)
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In this project we propose the continuous flow syntheses of 3 active pharmaceutical ingredients (APIs): i) ibuprofen; ii) cannabidiol; iii) axitinib (Figure i). In subproject (i) - ibuprofen synthesis - we intend to study the iodination of isobutylbenzene via electrosynthesis to then convert the iodinated intermediate into ibuprofen after two photocatalytic steps, similar to a methodology…
In this research project we propose the application of the methodologies recently developed in our research laboratory (LQBO-UFSCar) for the synthesis of bioactive molecules and active pharmaceutical ingredients (APIs) such as (-) - aritasone, favipiravir, and ibuprofen. For these syntheses, we will use continuous flow reaction systems, and simple solutions also developed in our laborator…
Studies on the photocatalyzed enantioselective synthesis of the API Brivaracetam are aimed by using enabling technologies for organic synthesis. We intend to use D-RhS photocatalysts and perform a photocatalytic screening using a high throughput reactor (12 channels) in batch and a continuous photoreactor, both developed on demand for these processes. Firstly, the synthetic approach will …
The objective of this project is to cover the costs for the visiting of Prof. D. Tyler McQuade of VCU-Virginia USA and allow interactions and scientific collaborations under the theme "Continuous Flow Chemistry", encompassing the two main institutions that have been doing research in this field in the State of São Paulo: UNICAMP and UFSCar. Several joint project discussions, a short cours…
(Only some records are available in English at this moment)
In this project, we propose the development of innovative syntheses of 3 important active pharmaceutical ingredients (APIs) that make up the drug kit for public calamity situations, as defined by the Ministry of Health in Brazil. Our proposal involves the study in both batch and continuous flow regimes, using sustainable processes such as electrosynthesis and photocatalysis in the synthet…
In this PhD project we propose to carry out a systematic study of reductive amination reactions via electrochemistry. Various reaction aspects will be evaluated with a focus on the selection of the best electrodes and the best activation surface techniques for these electrodes, in addition to different solvents, supporting electrolytes, pH and temperatures. The use of photoelectrocatalysi…
In this MsC project, we propose the synthesis of 2 relevant active pharmaceutical ingredients (APIs) with high demand in the pharmaceutical market, Buclizine and Cinnarizine, which are active ingredients of drugs used in brain disorders, nausea, vomiting, various syndromes and other socially relevant diseases. Our proposal involves batch and continuous flow development, using some photoca…
In this undergraduate project, we aim to develop a new synthetic route for isochromane and isochromene derivatives through cyclization reactions in electrosynthesis using sacrificial electrodes (Figure 1). From this approach, the project was conceived in two phases: Initially, from the derivatives of 2-alkynil-benzaldehydes (1) and 2-alkenil-benzaldehydes (2) we propose the synthesis of d…
In this project, we propose the application of the methodologies developed in recent years in our laboratory (LQBO-UFSCar) in the synthesis of the active pharmaceutical ingredient (API) ibuprofen. For this synthesis, we will use continuous reaction systems designed and built in our laboratory for photo and electrocatalysis, seeking to advance with the appropriate applications of these sol…
In this post-doctoral project, we aim to advance in the syntheses and studies on electrosynthetic fluorination reactions, applying these methodological approaches in the preparation of API's and compounds with potential biological activities, such as derivatives of oxazepines, indoles, pyrazines, pyrroles, imidazoles, among others, using electrosynthesis reactors coupled to a continuous f…
(Only some records are available in English at this moment)
The iminophosphoranes are important building blocks for C-N bonds formation, such as the aza-Wittig reaction and other relevant organic transformations. Herein, we propose to study the conversion of nitroarenes and triphenylphosphine to the correspondent iminophosphoranes via an electrochemistry approach. Subsequent studies involving photoelectrochemistry are also aimed at both batch and …
Studies on the direct photocatalyzed C-H arylation of quinolines, pyridines and styrenes with aryldiazonium and diaryliodonium salts will be performed using visible light. Different photocatalysts or the use of EDA complexes will also be explored in batch and flow conditions. To the best of our knowledge, photoarylation of these substrates has not been well-explored yet in the absence of …
In this project we intend to study the synthesis of quinones and naphthoquinones starting from the corresponding phenols and naphthols. The idea is to promote the oxidation of these precursors by the action of singlet oxygen (1O2) under continuous flow conditions (Photochemical Continuous Flow). The oxidizing species (1O2) will be generated by photocatalysis using different porphyrins as…
| 1 / 1 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 27 / 22 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 41 / 36 | All research grants and scholarships |
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