Cristina Helena dos Reis Serra

• Abstract

  The bioavailability of a drug is the determinant factor of clinical efficacy and it depends on the release of active ingredient from the dosage form and its absorption. Thus, the control of the extent and rate of absorption of an orally administered drug depends on two aspects: solubility in the physiological fluids and permeability through biological membranes. Based on these characteris…

  Evaluation of mechanisms involved in the permeability of antiretroviral drugs through in situ perfusion model in rats, AP.R

• Abstract

  Bioavailability studies evaluate the presence of the drug in the body from the administration of a pharmaceutical form over time. The in vitro-in vivo correlation relates to the establishment of a rational relationship between the biological properties, or parameters derived from those produced by a pharmaceutical form and its properties or physicochemical characteristics. The establishme…

  Bioavalability of furosemide complexed with beta cyclodextrin: in vitro - in vivo correlation evaluation from human volunteers, AP.R

• Abstract

  Bioavailability is the determining factor of drug clinical efficacy and it depends directly on permeability and solubility properties of the active substance . The Biopharmaceutical Classification System (BCS), based on these characteristics, has been proposed to work as a tool aiming at the development of pharmaceutical forms, whether it contains new drugs or not, with the objective of …

  In vitro permeability drugs evaluation in intestinal tissue of rats. Applications in biopharmaceutical classification, AP.R

(Only some records are available in English at this moment)

• Abstract

  The prediction of in vivo absorption has been shown as an interesting scientific area, especially with regard to new molecules discovery and development. Furthermore, some in vitro methods have been described and are broadly used despite their limitations, such as high costs, difficulties of maintenance during the experiment, and lack of standardization of protocols. Since its first attem…

  Membrane lipid composition impact on drug permeability using PAMPA assay, BP.IC

• Abstract

  The current project for bioavailability evaluation is integrated by project FAPESP (2010/03133-3) and by the PhD project from the student Marina de Freitas Silva (2009/14658-2), both entitled "Bioavailability of furosemide complexed with beta-cyclodextrin: in Vitro - in Vivo Correlation evaluation from Human Volunteers." The study has been approved by the Ethics Committee (CEP) from the F…

  Bioavailability evaluation of furosemide complexed with cyclodextrin tablets, BP.IC

• Abstract

  HIV (Human Immunodeficiency Virus) is the AIDS (Acquired Immune Deficiency Syndrome) causative agent. Drugs such as stavudine, lamivudine and zidovudina have been used in antiretroviral therapies to minimize the effects of immune suppression in infected individuals. The drugs absorption depends on its dosage form in the environment where it is absorbed, besides physiological and physicoch…

  Permeability study of antiretroviral drugs by in situ perfusion model. Application in the Biopharmaceutical Classification., BP.IC

(Only some records are available in English at this moment)