HIV (Human Immunodeficiency Virus) is the AIDS (Acquired Immune Deficiency Syndrome) causative agent. Drugs such as stavudine, lamivudine and zidovudina have been used in antiretroviral therapies to minimize the effects of immune suppression in infected individuals. The drugs absorption depends on its dosage form in the environment where it is absorbed, besides physiological and physicochemical factors. Permeability studies provide knowledge that allows waiver of bioequivalence studies (biowaiver) of some drugs. The use of in situ perfusion technique can predict the drug absorption and has been widely used because of its advantages. The intestinal absorption study of antiretroviral drugs in animals can clarify some doubts in regarding to the bioavailability reported in the literature. The purpose of this study is to standardize a protocol to study the permeability by the use of technique in situ perfusion of intestinal segments of rats Wistar to correlate data obtained from animals to humans.
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