Beatriz Simonsen Stolf

• Abstract

  Leishmaniasis, a group of diseases caused by parasites of the genus Leishmania, is endemic in 98 countries and has an estimated annual incidence of more than 1 million cases. The symptomatic infection has several clinical forms, which are divided into cutaneous, mucocutaneous and visceral. In Brazil, three dermotropic species are predominant, L. (V.) braziliensis, L. (L.) amazonensis, and…

  Identification of factors related to phagocytosis and survival of L. amazonensis by comparison of proteomes and analysis of mutants by CRISPR-Cas9, AP.R

• Abstract

  Leishmaniasis is a zoonotic disease caused by protozoa of the genus Leishmania that may be classified in tegumentary (TL) or visceral (VL) forms. In humans and other vertebrate hosts, Leishmania preferentially infects macrophages. Many factors affect the form and severity of the disease, mainly the species of Leishmania and the host immune response. CD100 (Sema 4D) is a glycoprotein of th…

  Role of sCD100 in in vitro and in vivo infection by different species of Leishmania, AP.R

• Abstract

  Leishmania ssp. are protozoan parasites responsible for a complex of diseases known as leishmaniasis. The parasite has two main forms: promastigote flagellated in the insect digestive tract, and amastigote inside macrophages of the vertebrate host. Survival and multiplication inside these macrophages are guaranteed by evasion mechanisms based on parasite virulence factors. Proteome analys…

  Role of cTXNPx and OPB in virulence and drug resistance in Leishmania L. amazonensis and search for new virulence factors by comparative proteomics, AP.R

(Only some records are available in English at this moment)

• Abstract

  Leishmaniasis is a complex of diseases caused by parasites of the genus Leishmania, endemic in 98 countries and responsible for more than 1 million cases every year. The human symptomatic infection has different clinical forms, which are grouped into tegumentary/cutaneous and visceral. The parasite is transmitted to man (and other vertebrates) by insect vectors, in which it remains in the…

  Analysis of the role of enolase and LABCG1 in L. (L.) virulence amazonensis using tags and silencing by CRISPR-Cas9, BP.DR

• Abstract

  Leishmania spp. are protozoan parasites that cause leishmaniasis, an endemic disease in more than 98 countries, responsible for more than 1 million new cases every year. The infection can manifest itself in several clinical forms in man, which can be grouped in tegumentary/cutaneous or visceral. The parasite is transmitted to hosts by the bite of female phlebotomine insects. During its li…

  Importance of oligopeptidase B (OPB) in the infection of macrophages by L. (L.) amazonensis, BP.MS

• Abstract

  Leishmaniasis is a zoonotic disease caused by protozoa of the genus Leishmania that may be classified in tegumentary (TL) or visceral (VL) forms. In humans and other vertebrate hosts, Leishmania preferentially infects macrophages. Some factors affect the form and severity of the disease, mainly the species of Leishmania inoculated by the insect vector and the host immune response. CD100 (…

  Role of sCD100 in macrophage in vitro infection by Leishmania (Viannia) braziliensis and Leishmania (Leishmania) chagasi and in in vivo infection by Leishmania (Leishmania) amazonensis, BP.PD

(Only some records are available in English at this moment)

• Abstract

  Leishmania ssp. are protozoan parasites responsible for a complex of diseases known as leishmaniasis. Present two main developmental forms: a flagellated promastigotes in the alimentary tract of the insect vector, and the amastigote no external flagellum, within cells of the mononuclear phagocytic system, preferably macrophages of the vertebrate host. The ability for survival and multipli…

  Enzymatic characterization of tryparedoxin cytoplasmic peroxidase of Leishmania (L.) amazonensis and effect of overexpression in resistance to oxidative stress and protein expression of the parasite, BE.EP.MS