Anna Karenina Azevedo Martins

• Abstract

  Obesity has been taking on alarming dimensions at the global level, which reflects changes in dietary and nutritional patterns. Associated with the pathogenesis of this condition is the increased peripheral resistance to insulin, which may be related to the increased risk that obese women have to develop gestational diabetes. Pregnancy, per se, is a condition where physiological resistanc…

  Study of the effects of progesterone and the hypercaloric diet on the interactions between pancreatic beta cell and adipose tissue, AP.R

• Study of the effects of progesterone and the hypercaloric diet on physiological aspects of female mice, BP.TT

• Abstract

  Pregnancy, by itself, is a disease that is observed to a physiological person in insulin and a progesterone is one of the hormones responsible for this condition, known as being a counterregulatory hormone. Associated with this picture has an obesity that has been taking the proportions in the global context of changes in the lifestyle. Together, both factors can lead to a metabolic condi…

  Study of the effects of progesterone and hypercaloric diet on insulin secretion and pancreatic beta cell mass, BP.IC

• Abstract

  During pregnancy occur great adjustments on maternal organism. The carbohydrate metabolism is one of the most affected aspects. Significant changes are observed on the insulin sensitivity, however the variations of glycemia are normally slight, because of the plasticity of pancreatic beta-cells. Nevertheless, evidences suggest that high concentrations of estrogens and progestogens in preg…

  Effect of the steroid hormones pregesterone and estriol on the proliferation of RINm5F cells - an in vitro model for the study of beta cell physiology in pregnancy, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Type 2 diabetes (T2D) is a complex disease characterized by progressive b cell failure in a context of insulin resistance. Genome-wide association studies (GWAS) have identified >500 genetic loci, that alter T2D risk by affecting insulin secretion or sensitivity. The molecular mechanisms through which these gene variants confer T2D risk remain ill understood. Expression quantitative trait…

  In vitro study of the protective role of CCND2 gene variants against type 2 diabetes in obesity: looking at the crosstalk between adipose tissue and pancreatic b cells, BE.PQ