CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
MD and PhD degrees (in 1999 and 2005, respectively) from the State University of Campinas, Sao Paulo, Brazil (UNICAMP). Residency training in Anatomic Pathology and Cytopathology at Hospital de Clinicas (UNICAMP), 2000-2003. Board certified in Anatomic Pathology and Cytopathology by the Brazilian Society of Pathology and the Brazilian Medical Association (in 2002). Professor of Pharmacology and Pathology at the School of Medical Sciences (Department of Translational Medicine) - UNICAMP (2009-). Concentrates in Cancer Stem Cell biomarkers as targets for the development of new therapeutical strategies and in the Toxicological Pathology of Nanomolecules. (Source: Lattes Curriculum)
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Neoplastic or cancer stem cells (CSCs) are tumor cells which are able to mimic phenotypic and functional features of adult stem cells, such as self-renewal and multilineage potential. In addition, CSCs are resistent to the majority of xenobiotics (including classic antineoplastic drugs) since they present low proliferative index and express efflux pumps (such as Pgp and ABCG2). These char…
In malignant neoplasms, angiogenesis seems to facilitate tumour growth and metastasis, thus, bearing a potential role in diagnostic/prognostic assessment, as well as in the development of new therapeutic strategies. However, the relative importance of such a role is variable from one entity to another, probably reflecting biological differences between tumours, as well as limitations or m…
Breast cancer is one of the main causes of death from malignant neoplasms in females worldwide and, for this reason, an important object of research involving the use of neoplastic stem cells (NSCs) as a primary pharmacological target. According to cumulative evidence, NSCs play a fundamental role in the development and maintenance of malignant neoplasms, especially in the face of therape…
Cancer represents a significant epidemiological and economic challenge worldwide. Managing this group of diseases is marked by a shortage of curative and low-toxicity therapeutic approaches, especially when patients are in advanced stages. In particular, there is a clear lack of drugs capable of inhibiting neoplastic stem cells (NSCs) - one of the primary factors responsible for therapeut…
Cancer constitutes a group of heterogeneous diseases characterized by the disordered, rapid and autonomous proliferation of cells with changes in differentiation and which can spread locally or systemically. It has high prevalence and morbidity and mortality worldwide and, for this reason, represents a critical public health problem. Ovarian cancers, in particular, account for 3% of ca…
(Only some records are available in English at this moment)
Stem cells (SCs) are characterized by the capacity for self-renewal and multilineage differentiation and participate actively in countless physiologic and pathologic processes. Recently, in a new paradigm for carcinogenesis, SCs have been regarded as responsible for the origin, morphologic heterogeneity and self-renewal of malignant neoplasms. In support of this theory, it has been detect…
(Only some records are available in English at this moment)
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| 4 / 4 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 14 / 12 | All research grants and scholarships |
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