Vladmir Cláudio Cordeiro de Lima

• Abstract

  The use of high dose chemotherapy with hematopoietic stem cell rescue or bone marrow transplantation (BMT), is considered a successful treatment option for a wide variety of neoplastic, metabolic and immune diseases. However, complications such as infections, mucositis, diarrhea, respiratory failure and sepsis are frequent, contributing to increased mortality rates. The complications in a…

  Serological markers of inflammation as predictors of complications in patients undergoing high-dose chemotherapy with hematopoietic stem cell rescue autologous, AP.R
• Neoadjuvant chemotherapy based in platine in tripe-negative breast cancer: phase II study, AP.R

• Abstract

  Melanoma is a cancer that originates in melanocytes and their primary sites include skin, uvea, leptomeninges and mucous membranes, skin being the most common site of involvement (90%). Its incidence has increased in recent decades. In Brazil, the estimate is 5930 new cases in 2010, with 1990 cases in the state of Sao Paulo. The risk of death is higher in patients with melanoma detected i…

  Evaluation of the expression profile of genes modulated by TNF and melphalan in mixed cultures of endothelial cells, melanoma cells and macrophages, AP.R

(Only some records are available in English at this moment)

• Abstract

  As the tumor evolves, an immunosuppressive tumor microenvironment (TME) emerges and, as a result, immune cells become dysfunctional and lose the ability to eliminate tumor cells. In this sense, NK cells lose their ability to produce cytotoxic granules and thus become incapable of effectively destroying tumor cells. Immune checkpoint inhibitors (ICI), such as anti-PD1 and anti-CTLA-4, can …

  Boosting antitumor activity of NK cells from triple-negative breast cancer patients through epigenetic modulation, BP.MS