Luciano Cesar Pontes de Azevedo

• Abstract

  In Brazil, about one-third of the intensive care beds are occupied by septic patients, with a mortality rate of 55.7% compared to the 26% worldwide averages reported recently. In this project we intend to integrate basic and clinical research in Sepsis, ranging from the pathogenesis and development of intervention strategies to epidemiological studies that allow us to know the reality of …

  Sepsis: mechanisms, therapeutic targets and epidemiology, AP.TEM

• Abstract

  Sepsis is a clinical condition with high morbidity and mortality, often complicated with cardiac dysfunction. Cardiac dysfunction in sepsis occurs by the release of inflammatory mediators generating reduction of myocardial contractility. There are no established treatments for myocardial failure during sepsis, besides the usual support with vasoactive drugs. Previous studies suggest that …

  Cardiovascular and inflamatory effects of insulin, glucose and potassium therapy in an experimental model of sepsis, AP.R

• Abstract

  Sepsis' pathogenesis is characterized by exacerbated inflammatory response and increased production of reactive oxygen species (ROS). ROS may be released by circulating microparticles produced upon activation of several cell types. We previously demonstrated the presence of a subtype of microparticles (exosomes) in the circulation of septic shock patients. Exosomes may induce apoptosis in…

  Evaluation of micro RNA profile and expression of genes related to oxidative stress and inflammatory response in septic patients' microparticles, AP.R

(Only some records are available in English at this moment)