CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Undergraduated in Pharmaceutical Sciences from São Paulo University (1978), Master's at Psycopharmacology from São Paulo Federal University (1991) and Ph.D at Biochemistry from São Paulo University (1995). Post-doctoral training at University of Southern California (1997-2000).Experience in Biochemistry acting on the following subjects: proteasome, oxidative stress, proteolysis, and protein S-glutathionylation. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The proteasome is a multicatalytic and multimeric protease component of the ubiquiitin-proteasome system (UPS). The proteasome is formed by a catalytic unit named 20S (20SPT) flanked or not by regulatory units, being the 19S the most abundant. When interacting to the 19S complex it is termed 26S proteasome (26SPT), responsible for the degradation of poly-ubiquitinylated proteins involved …
The proteasome is a proteolytic complex responsible for the degradation of intracellular proteins labeled by a poli-ubiquitin chain. It consists of a central catalytic unit named 20S proteasome (20S PT) coupled to regulatory units (19S or 11S). The 20S PT is able to degrade oxidized proteins independently on poly-ubiquitylation. The 20S PT is constituted of a central core formed by two he…
(Only some records are available in English at this moment)
The proteasome is a protein complex of utter importance for cellular homeostasis, as it is one of the main mechanisms of intracellular proteolysis. The proteasome is made up of a catalytic unit called 20S, which can sometimes be coupled to the 19S regulatory unit at one end (forming the 26S proteasome) or at both ends (forming the 30S proteasome). When associated with the 19S regulatory u…
The present proposal is inserted in the research field developed by our group, that refers to the role of the redox modulation of the proteasome on protein metabolism and, therefore in cellular homeostasis. The proteasome is a protein complex responsible for the degradation mainly of proteins regulated by the polyubiquitination process involved in regulation and cell signaling, antigenic …
The proteasome is a complex responsible by the intracellular protein degradation, protecting the cells against oxidized, misfolded and mutant proteins. In the central core, namely 20S, are localized the catalytic sites. As already demonstrated, the 20S proteasome activity is regulated by S-glutathiolation that consists of reaction between reduced glutathione and proteasome Cys residues ox…
Present proposal is part of the project upon the Screening for Modulators of the 20S Proteasome (BioProspecta; Proc FAPESP: 06/06969-0; Coordenação: Dra. Marilene Demasi, Laboratório de Bioquímica e Biofísica - Instituto Butantan). Among the modulators isolated thus far, one of them refers to a catalytic activator of the 20S proteasome named Tnp1. Preliminary studies with that peptide sho…
(Only some records are available in English at this moment)
| 9 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 5 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 21 / 15 | All research grants and scholarships |
| Associated processes | |