CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Pontifícia Universidade Católica de Campinas (1989) and ph.d. at Endocrinologia e Metabologia from Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (1999). Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: acth, ddavp, adrenal, síndorme de cushing and doença de cushing. (Source: Lattes Curriculum)
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Arterial hypertension (AH) is an important cardiovascular risk factor, with an estimated prevalence of 10 to 40% of adults in developed countries. AH is primary or essential in the majority of the cases, but the prevalence of secondary AH increases to around 30% in young adults. Among patients with resistant AH, screening for primary aldosteronism (PA) and for catecholamine-secreting tumo…
Adrenal cortex carcinoma (CCS) is a rare and extremely aggressive malignant neoplasm. The southern and southeastern regions of Brazil are characterized by a significantly higher incidence of this condition in the pediatric population, which is 10 to 15 times higher than the global incidence due to the high prevalence of a specific germinative allelic variant in the TP53 gene (R337H). In t…
Cushing syndrome (CS) results from chronic excess of cortisol production and represents and archetype of metabolic syndrome (MS). The MS is a condition defined as a complex of interconnected cardiovascular risk factors such as (obesity, diabetes, blood hypertension and dyslipidemia). It is estimated that 2/3 of CS patients fulfill the criteria for MS. PMAH is a cause of CS, usually diagno…
Around 10% of pituitary tumors are ACTH-secreting (corticotropinomas) and causes Cushing's disease, characterized by autonomous secretion of ACTH which stimulates the chronic and excessive production of cortisol by the adrenal glands. In most patients with Cushing's disease, corticotropinomas are microadenomas (<10 mm) and 4-10% of these patients have macroadenomas (e 10 mm). Macroadenoma…
(Only some records are available in English at this moment)
Bilateral Macronodular Adrenocortical Disease (BMAD), first described in 1964 by Kirshner et al (1), is a rare (less than 2%) heterogeneous condition associated with endogenous Cushing's Syndrome (CS). BMAD is characterized by the formation of adrenal macronodules, usually bilateral, which secrete mainly cortisol in a variable manner and consequently greatly influence the phenotypic expre…
Adrenal incidentalomas (AI) are adrenal masses larger than 1 cm, incidentally discovered during imaging studies conducted to investigate conditions unrelated to the adrenal glands. Most of these masses are composed of benign adrenocortical adenomas, which can be non-functioning or associated with autonomous cortisol secretion, ranging from clinically evident Cushing's syndrome to subclini…
Primary Bilateral Pigmented Nodular Adrenocortical Disease can be classified into Isolated Adrenocortical Micronodular Disease (i-MAD) and Primary Pigmented Nodular Adrenocortical Disease (PPNAD). PPNAD may or may not be associated with Carney Complex (CNC), a hereditary syndrome, with autosomal dominant inheritance and variable penetrance, composed of multiple neoplasms, such as benign a…
Primary macronodular adrenal hyperplasia is a rare cause of Cushing's syndrome and is more often diagnosed as bilateral adrenal incidentalomas with subclinical cortisol production. Current findings indicate that bilateral macronodular adrenal hyperplasia is more frequent and genetically determined than previously believed. Considering the role of paracrine adrenocorticotropic hormone prod…
Primary Macronodular Adrenal Hyperplasia (PMAH) is one of the causes of Cushing's syndrome. It is characterized by the presence of functioning in the adrenal benign macronodules (usually> 1 cm) and sustained by increased production of cortisol, independent of circulating ACTH pituitary. The PMAH may present sporadically or be inherited (familial) with clinical manifestation mainly between…
Multiple endocrine neoplasias (MENs) are tumoral familial syndromes which involve several endocrine glands (pituitary, parathyroids, thyroid, endocrine pancreas and adrenal). Patients with MEN type 1 (MEN1) usually carry inactivating mutations in the MEN1 gene, while patients with MEN type 2 (MEN2) usually carry activating mutations in the RET proto-oncogene. Recently, patients with MENs …
| 1 / 1 | Ongoing grants |
| 5 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 3 | Completed scholarships in Brazil |
| 17 / 11 | All research grants and scholarships |
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