CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's in Pharmacy from Faculdade de Ciências Farmacêuticas da USP (1972), Master's in Pharmacy (Txicology) from Universidade de São Paulo (1976) and PhD int Toxicology from Universidade de São Paulo (1980). Has experience in Toxicology, acting on the following subjects: antioxidants, mechanism of photoprotection and antineoplastic activity of Pothomorphe umbellata and 4-nerolidylcatechol , toxicology, risk assessment, oxidative stress, UV induce skin lesion, hepatotoxicity and alternative methods to animal experimentation. (Source: Lattes Curriculum)
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Environmental pollution is a major concern worldwide, specifically, air pollution by particulate matter (PM) that has been linked to the development of many diseases, among them the Atopic Dermatitis (AD). AD is characterized by chronic inflammation of the skin, thus compromising the quality of life of patients. When exposed to PM the skin undergoes structural and functional changes of th…
Ultraviolet (UV) has detrimental effects on human skin and can result in clinical conditions such as burns, immunosuppression, premature aging and cancer. There are differences in the pattern of cellular damage from UVA and UVB waves. While UVA indirectly damage DNA by the formation of reactive oxygen species, UVB can directly reach the DNA, resulting in the formation of photo-products, s…
Carbaryl (1-naphthyl methylcarbamate), a broad spectrum insecticide widely used in agriculture and domestic environment, has recently been associated with the development of cutaneous melanoma in an epidemiological cohort study with U.S. farm workers. Parallelly, ultraviolet radiation is known to be the main etiologic factor for skin cancer development. Although comprehensive and well des…
(Only some records are available in English at this moment)
When ultraviolet radiation (UV) reaches the skin, it can lead to molecular and biological alterations as erythema, sunburning and tanning after acute exposure, or even skin cancer and photoaging, in cases of chronic exposure. Different mechanisms are involved in the development of these conditions, highlighting the direct damage to DNA or the formation of reactive oxygen species that can …
Cutaneous melanoma, one of the most aggressive form of skin cancer, is considered a major global public health problem and its incidence has grown rapidly in recent years, including Brazil. Therapies available for the advanced stage of melanoma, however, are far from satisfactory and effective, given that this cancer is refractory to most chemotherapeutic medicines available and that the …
(Only some records are available in English at this moment)
Toxicogenomics is rapidly evolving towards the discovery of useful biomarkers of toxicity, evaluation of multiple toxicity pathways, and elucidation of organisms' responses to environmental stress. Biological responses to environmental exposures can be very dynamic events, since a compound may have multiple modes of action, each with multiple key events. Therefore investigation of possibl…
| 29 / 5 | Completed research grants |
| 20 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 50 / 11 | All research grants and scholarships |
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