Nancy Amaral Reboucas

• Abstract

  In the research project, this equipment is essencial for the experiments designed to investigate the interactions between proteins in cells expressing fluorescent or luminescent protein tags (fusion proteins with luciferase) by FRET and BRET techniques, respectively. Due to its multi-function, this equipment will replace the Nonodrop spectrophotometer (asked in the thematic project 2013 /…

  Multi-User Equipment approved in grant 2013/11093-0: multi-mode microplate reader model synergy H1M- (monochromator based) Bio-Tek instruments, Inc. (em substituição a: Mithras LB 940 - Berthold), AP.EMU

• Abstract

  Angiotensin receptor type I (AT1R) activation by angiotensin II (AngII) induces complex mechanisms of intracellular signaling, which result in increase of NaCl and H2O reabsorption in renal tubules. These effects are important in developing and maintenance of arterial hypertension. Our goal with the present study is elucidate new aspects of the AT1R functioning, with special interest on t…

  Molecular mechanisms involved in modulation of AT1R by ATRAP and associated proteins and effects on renal tubular ion transport, AP.R

• Abstract

  This thematic project includes projects having in common the study of ion transporters in membranes. Most of these projects focalize the study of epithelial cells of the kidney, with the exception of two, which analyze glial neurons/cells and osteoclasts. In neurons, the effect of phenylpropenes on voltage sensitive sodium channels will be investigated, and in glial cells, purinergic meta…

  Molecular and functional study of ion transporters in membranes, AP.TEM

(Only some records are available in English at this moment)

• The role of ATRAP (AT1R associated protein)on NHE3 regulation mediated by Angiotensin II, BP.IC