CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia-Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and doctorate at Biochemistry from Universidade de São Paulo (2007). Has experience in Biochemistry, acting on the following subjects: proteólise muscular, diabetes mellitus, streptozotocin-diabetic rats, estreptozotocina and pentoxifylline. (Source: Lattes Curriculum)
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Various pathogenic events contribute to the development of complications observed in diabetes mellitus (DM) and obesity, including glycoxidative stress. Chronic hyperglycemia results in an increased generation of reactive oxygen species (ROS) that exceeds the capacity of antioxidant defenses, resulting in functional impairments of biomolecules through dicarbonyl stress in proteins and lip…
A combination among rapid urbanization, nutrition transition, and sedentary lifestyle accounts for the epidemic proportions of type 2 diabetes mellitus (T2DM), which is characterized by insulin resistance and pancreatic dysfunction. In uncontrolled DM, microvascular and macrovascular complications are observed. Impairments caused by glicative and oxidative stress (due to hyperglycemia) an…
It has been demonstrated that the inhibitory effect of catecholamines in the protein breakdown in skeletal muscles occurs, at least in part, through stimulation of beta2-adrenoceptors and increase in the intracellular levels of cyclic AMP (cAMP), involving the participation of two signaling cascades: i) an EPAC (Exchange protein directly activated by cAMP) dependent pathway, which leads t…
Diabetes mellitus (DM) is a chronic metabolic disease characterized by deficiency in the insulin production by pancreatic beta cells and/or by resistance of target tissues to the actions of this hormone. Chronic hyperglycemia is considered one of the main causes of the establishment and maintenance of microvascular and macrovascular diabetic complications, which are directly related to th…
Diabetes mellitus (DM) is a chronic endocrine disease characterized by insulin resistance in target tissues and pancreatic dysfunction. The DM, especially type 2, is closely associated with an increase in the prevalence of obesity. Most of the diabetic complications are related to the increase in the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), w…
The maintenance of hyperglycemia for long periods is responsible for the glycoxidative stress, which participates in the onset and progression of diabetes mellitus (DM) complications. It is raising the interest in the search for complementary therapeutic options to the conventional therapies for DM, especially aiming the glycoxidative stress. Capsicum chinense pepper species have been stu…
Increase in the intracellular levels of cyclic AMP (cAMP) is an essential event participating inthe inhibition of skeletal muscle protein degradation by catecholamines, after binding to beta 2-adrenoceptors. Two intracellular cAMP-dependent effectors seem to be involved in the antiproteolytic response of cAMP in the skeletal muscle: I) EPAC (Exchange protein directly activated by cAMP) th…
Diabetes mellitus (DM) is a chronic endocrine disease characterized by insulin resistance in target tissues and pancreatic dysfunction, where there is also the establishment of glyco-oxidative stress, marked by the generation of reactive species that lead to the progression of tissue damage. Type 2 DM is correlated with obesity, where exacerbated and harmful inflammatory responses are com…
The knowledge of the mechanisms regulating skeletal muscle mass is of great relevance, since the excessive loss of muscle mass associated with various clinical conditions can lead to serious health complications. Considering the evidences for the role of cyclic adenosine 3,5-monophosphate (cAMP) signaling in the inhibition of muscle proteolysis by catecholamines and beta2-adrenergic agoni…
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 4 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 12 / 10 | All research grants and scholarships |
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