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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
José Luiz Proença Módena in research grants and scholarships supported by FAPESP.
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Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are arboviruses that cause acute and chronic musculoskeletal disease and are capable of infecting the central nervous system (CNS). However, the mechanisms underlying neuropathogenesis and neuroinvasion associated with CHIKV and MAYV infection remain poorly understood. Our preliminary data demonstrate that dendritic cells (DCs) and T lymph…
Emerging and reemerging diseases are a public health concern in Brazil and, due to several factors, have a great impact on the Amazon region. This region is characterized by great biodiversity and it is largely populated by a socially vulnerable population. In addition, it has been suffering from recent anthropological activities that promote environmental degradation. In fact, official d…
Background: Oropouche virus (OROV) is a neglected insect-borne orthobunyavirusthat causes a febrile illness, neurological disease, and pregnancy complications inhumans across an endemic area spanning South and Central America. The hostfactors associated with disease pathogenesis have nonetheless remained obscure,and little is known about the immune determinants of protection against OROV.…
Em 2024, o 35º Congresso Brasileiro de Virologia em conjunto com 19º Encontro de Virologia do Mercosul será realizado na cidade de Foz do Iguaçu e reunirá virologistas que atuam em diversas regiões do Brasil e em outros países da América Latina, América do Norte, Europa e outras regiões. O programa científico desde ano foi montado de forma a integrar diferentes áreas da virologia, organiz…
(Only some records are available in English at this moment)
Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are arthritogenic alphaviruses transmitted by mosquitoes, posing a public health threat due to the occurrence of explosive outbreaks and the geographic expansion driven by urbanization and vector adaptation, which is globally distributed. CHIKV is mainly transmitted in urban cycles worldwide, whereas MAYV remains restricted to enzootic cyc…
The functional integrity of pancreatic beta cells is essential for maintaining glycaemic homeostasis and their dysfunction or loss is directly linked to the development of diabetes mellitus. Increasing evidence implicates viral infections as potential triggers of beta-cell injury and subsequent autoimmunity, particularly in type 1 diabetes, with enteroviruses such as coxsackie B viruses b…
Despite international appeals regarding the importance of biodiversity and the maintenance of the Amazon ecosystem, our country has faced a weakening of public policies to combat deforestation in the Amazon, with an increase in the deforested area in recent years. In this postdoctoral project, we intend to contribute to the understanding of how deforestation activities (including road con…
(Only some records are available in English at this moment)
Emerging viruses are a major public health problem, as they can have a major impact on an unimmunized population. The urban sprawl of cities and human encroachment into forest areas have contributed to expanding the life cycle of arthropod-borne viruses in peri-urban and urban environments. The mayaro virus is transmitted to mammals by the bite of the Haemagogus janthinomys hematophagous …
The Oropouche (OROV) and Mayaro (MAYV) viruses are neglected arboviruses, which circulate mainly in the Amazon region and have great potential for dissemination to new areas of Latin America or other regions of the globe. They are etiologic agents that cause exanthematous febrile illnesses that can progress to severe clinical cases, such as, neurological complications or chronic arthralgi…
Oropouche Orthobunyavirus (OROV) is an arbovirus associated with cases of febrile illness in the Amazon region. A high genetic diversity between orthobunyaviruses generated by genetic rearrangement or mutations makes the development of compounds with directly antiviral activity challenging, thus, host-targeted drugs looks a good alternative to develop antivirals against these pathogens. O…
(Only some records are available in English at this moment)
Mayaro virus (MAYV) is a neglected arthritogenic arbovirus endemic to Latin America and the Caribbean, with a high potential to lead to future epidemics. Mayaro causes Mayaro fever, an illness with debilitating symptoms, such as fever, headache, polyarthralgia, and in some cases, neurological complications. Recent studies and our preliminary data indicated that gamma delta T cells can pla…
Oropouche orthobunyavirus (OROV) is an emerging arbovirus that causes an exanthematous fever disease associated with neurological complications in some infected patients in the Amazon region from South American countries. Golden hamsters, newborns, and IRF5-/- infected animals are vulnerable and usually die from meningoencephalitis. Thus, since it has been shown that OROV can cross the bl…
The Chikungunya virus (CHIKV) is an emerging arbovirus present in tropical and subtropical regions. One of the major complications associated with CHIKV infection are chronic manifestations such as arthralgia and arthritis. The chronic disease resulting from CHIKV infection has similar characteristics to rheumatoid arthritis (RA) in which dendritic cells (DCs) are implicated in the pathog…
The Oropouche virus (OROV) is an arbovirus with potential to cause epidemics in the most populated regions of Brazil. Individuals infected with OROV develop a febrile illness, which can progress to neurological and hemorrhagic complications. Furthermore, an increased incidence of abortion was reported during major OROV epidemics. However, the pathogenetic mechanisms associated with the he…