bachelor's at Medicina from Universidade de São Paulo (1980), master's at Physiology from Universidade de São Paulo (1986) and doctorate at Physiology from Universidade de São Paulo (1988). He is currently full professor at Universidade de São Paulo. Has experience in Physiology, focusing on Physiology of Organs ans Systems, acting on the following subjects: comportamento de defesa, hypothalamus, defensive behavior, hipotalamo and comportamento predatorio. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Los circuitos de la caza |
| Hunting circuits |
| The paths of fear |
| Los caminos del miedo |
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| News published in Agência FAPESP Newsletter about the researcher |
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This proposal consists of three research projects. In the first project, we will evaluate a site located in the pontine periventricular region called nucleus incertus (NI) which is a critical element in the process of behavioral activation. We will initially investigate several behavioral situations in which we will seek the contrast between high and low behavioral activation. In these di…
Olfactory fear conditioning is a powerful and innovative framework to model intergenerational stress because it allows us to "tag" a stressor in one generation (odor + US) and then follow the tag (odor) in the future offspring at the level of structure (visualize olfactory neurons), function (flow of olfactory information from the periphery into the central nervous system), and genetics (…
Dr. Caroline Blanchard's visit to our lab will be very helpful to develop ongoing projects in our lab and new proposals to understand the neural basis of defensive aggression. Among the ongoing projects in our laboratory, Dr. Caroline Blanchard will be working in two specific projects, which are part of our FAPESP research grant Neural Basis of Fear and Aggression (Project # 2014/05432-9)…
(Only some records are available in English at this moment)
The hippocampus has been implicated in-memory processing, spatial navigation, and emotional responses. The Subiculum (SUB) represents one of the "endpoints" of the "trisynaptic circuit" and one of the primary sources of "extrinsic" hippocampal projections. The ventral SUB, in particular, receives information regarding contextual threats from the basolateral amygdala and, on the other hand…
The cuneiform nucleus (CUN) is a midbrain structure located laterally to the caudal part ofthe periaqueductal gray matter. Hodological studies show that CUN is part of the neuralsystem that integrates anti-predatory defense responses. Importantly, CUN has bothglutamatergic and GABAergic cell bodies. Our laboratory's preliminary findings showed alarge overlap of the CUN glutamatergic a…
(Only some records are available in English at this moment)
The cuneiform nucleus (CUN) is a midbrain structure located laterally to the caudal part of the periaqueductal gray matter. Hodological studies show that CUN is part of the neural system that integrates anti-predatory defense responses. Importantly, CUN has both glutamatergic and gabaergic cell bodies. Preliminary findings from our laboratory have shown that optogenetic stimulation of bot…
Previous studies from our group showed that GABAergic neurons in the supraoculomotor (Su) region directly innervate the dorsal part of the dorsal periaqueductal gray matter (PAG). This investigation's hypothesis is based on the fact that the withdrawal of GABAergic inhibition from the Su > dorsal PAG pathway leads to an increase in innate fear, organized by the dorsal PAG, with prejudice …
The GABAergic neurons of the rostral Zona Incerta (ZIr) directly innervate the excitatory neurons of the dorsal periaqueductal gray matter (dPAG) and modulate the defense behavior. The scope of this work is to determine through optogenetic techniques and using transgenic mice expressing CRE-recombinase in GABAergic neurons, how the GABAergic influences in the dorsal PAG modulates the gain…
(Only some records are available in English at this moment)
The cuneiform nucleus (CUN) has traditionally been associated with locomotor activity, and many studies have considered the CUN to be part of the locomotion system. As a result, this structure has been viewed as a potential target for deep brain stimulation in Parkinson's disease (PD). However, recent studies have shown that the CUN has strong bidirectional connections with the dorsolater…
Recent technological advances open up causal investigation and specificity for the fast timescales of natural nervous system communication enabling an unprecedented level of hypothesis-testing precision. To understand how neural circuit activity controls behavior, experimental interventions should be performed with genetic, anatomical and temporal precision. Genetically encoded Ca2+ indic…
It is well known that the spatial location of an individual towards a potential threat determines the nature of the fear response. Depending on the proximity of the threat, an individual may display a freezing, avoidance or a fight response. One form of avoidance that has been recently investigated is the signaled active avoidance (AA) The neural circuits implicated are now being well inv…
The dorsal premammillary nucleus (PMd) represents one of the most mobilized sites during social agonistic encounters and provides strong projections to the dorsal part of the periaqueductal gray (dPAG) and the ventral part of the anteromedial thalamic nucleus (AMv). In the present study, we plan to study the role of the PMd and its main targets (i.e., dPAG and AMv) in the innate and conte…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 18 / 15 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 39 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 67 / 46 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID