Graduated in biological science and PhD at the Physics Institute of São Carlos, from the University of São Paulo, in the area of protein crystallography and characterization protein-ligand complexes. Four years of post-doctoral experiences on target validation and early drug discovery against neglected diseases, two of those at the Research Unit for Tropical Diseases at De Duve Institute of Cellular Pathology, Brussels. At the present, is PI in the LNBio where coordinates distinct projects on target-based HTS and structure-based hit optimization. (Source: Lattes Curriculum)
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The validation of a molecular target is a fundamental step in the drug research and development process. This project aims to advance the characterization and validation of four "potential" targets of the protozoan Trypanosoma cruzi, which causes Chagas disease. These targets are the enzymes L-threonine dehydrogenase (TcTDH), inosine-5-monophosphate dehydrogenase (TcIMPDH), NADPH-dependen…
The discovery of drugs against Chagas' disease lacks the identification and characterization of new molecular targets. In recent years, my research group has been dedicated to studying the structure and function of key enzymes of T. cruzi metabolism, with an emphasis on NADP-dependent dehydrogenases. The enzymes glucose-6-phosphate dehydrogenase (TcG6PDH), isocitrate dehydrogenase (TcIDH)…
The enzyme glucose-6-phosphate dehydrogenase catalyzes the first step of the pentoses phosphate pathway through the oxidation of glucose-6-phosphate (G6P) into 6-phosphoglucolactone with the reduction of NADP+ to NADPH. The TcG6PDH has been studied by our group as one of the molecular targets for drug development against Chagas disease. Among the recent finds of our group are: the discove…
The NADPH acts as the cofactor for enzymes that participate in several processes essential for the cellular homeostasis, like: lipid and cholesterol biosynthesis, production and neutralization of reactive oxygen and nitrogen species. The enzymes glucose-6-phosphate dehydrogenase (G6PDH), 6-phophogluconate dehydrogenase (6PGDH), isocitrate dehydrogenase (IDH) and malic enzyme (ME) are rela…
Chagas Disease (CD) caused by Trypanosoma cruzi is a public health problem in Latin America. Despite killing thousands of people every year and be expanding to other continents, CD treatment boils down to a single drug with inadequate safety profile and efficacy. One of the difficulties in developing new medicines for CD is related to the scarcity of validated targets for the development …
Leishmaniasis is a parasitic disease associated with infection by flagellate protozoa of the genus Leishmania ssp. Currently all available options for the treatment of this disease have limited use due to the development of parasite resistance, difficulties in administration, long period of treatment, toxicity or high cost. Glucose-6-phosphate isomerase (PGI) is considered as a promising…
American trypanosomiasis is an infectious disease caused by the protozoan Trypanosoma cruzi. The acute phase is the only stage with treatment, which is made with highly toxic drugs . The research of novel metabolic targets might lead to the development of new effective drugs to the chronic phase of the disease. Enzymes that produce NADPH are considered promising targets, since the reducti…
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Leishmaniasis is a parasitic disease with over a million new cases occurring every year. Besides its severity, leishmaniasis treatment is still challenging because all available drugs have important limitations, highlighting the urgent need to develop new drug candidates. Glucose-6-phosphate isomerase (PGI) is considered a promising molecular target for the development of antiparasitic dr…
Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi. The acute phase of this condition is the only stage amenable to drug treatment although these therapies can be highly toxic. Research into novel metabolic targets might lead to the development of new more effective drugs that target all stages of this infection. Dehydrogenase enzymes such as glucose-6-phospha…
According to the World Health Organization (WHO) it is estimated that 7-8 million people are infected with Trypanosoma cruzi worldwide. Despite the socioeconomic and public health impacts of Chagas disease, the available drugs lack desired safety and efficacy profiles, creating an urgent need for new therapeutics. The enzyme glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the first li…
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 4 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 16 / 12 | All research grants and scholarships |
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CV Lattes
ORCID