CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Chile
bachelor's at Tecnólogo Médico from Universidad de Antofagasta (1999). Has experience in Parasitology, focusing on Parasite Protozoology, acting on the following subjects: trypanosoma cruzi, formas metacíclicas, infecção oral, gp82 recombinant and e. coli invasion. (Source: Lattes Curriculum)
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CD200/CD200R complex are part of the immune checkpoint regulatory system. As such, CD200 ligand plays a pivotal role in the host immune response when bound to its receptor (CD200R) by causing suppression of proinflammatory responses. While CD200R is mainly expressed in the innate immune system cells such as macrophages, CD200 is ubiquitously present in different cell types, except in macr…
The immune checkpoint inhibitory mechanism mediated by the ligand CD200 and its receptor CD200R have been described to play a critical role in the host immune response, favoring Leishmania infection. While CD200R is mainly expressed in cells of the innate immune system such as macrophages, the ligand CD200 can occur in many different cell types. Our previous work has shown that macrophage…
There are numerous gaps in our knowledge about the strategies used by Leishmania species to survive in the within macrophages, among them, parasite survival in the harsh environment of the phagolysosome, and modulate the immune response mediated by this cell. The main objective of the proposed study is to analyze the molecules induced in the host cell in response to parasite infection tha…
Macrophages are the main target cells of parasites of the genus Leishmania, the causative agent of leishmaniasis. These parasites evade the microbicidal responses of macrophages to survive intracellularly. Several studies show that L. amazonensis amastigotes modulate immune-regulatory molecules, such as the surface ligand CD200 and its receptor (CD200R), a host inhibitory complex that par…
Protozoa of the genus Leishmania have developed different strategies to survive in a hostile environment such as the phagolysosome of the immune cells of the host. Several data in the immunobiology of Leishmania have emerged over the years, but there are still many gaps in knowledge about the characteristics presented by various species of Leishmania that promote different pathologies and…
Leishmaniasis is a tropical disease caused by the intracellular obligate protozoan from the genre Leishmania. Its cycle of transmission is mediated by the bite of the phlebotomus insect. The infective forms of the parasite are the metacyclic promastigote and amastigotes. Depending on the Leishmania species and the immunological state of the host, there could be established different manif…
Parasites of the genus Leishmania are intracellular protozoan responsible to cause a complex of diseases called leishmaniosis. Once inside of the host, these parasites are phagocyted by defense immune cells, such as macrophages. Through the interaction of Toll-like receptors (TLRs), macrophages are activated and initiate the process of pathogen destruction. However, the parasites are capa…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 4 | Completed scholarships in Brazil |
| 11 / 8 | All research grants and scholarships |
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