CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Hemocentro de Ribeirão Preto (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Calado graduated in Medicine from Universidade de São Paulo in 1997 and received his PhD in Medical Sciences [Ribeirão Preto] from Universidade de São Paulo in 2003. Dr. Calado is Professor of Medicine (Hematology) at the University of São Paulo at Ribeirão Preto Medical School and his research expertise is in Medicine, focusing on Hematology, acting on the following subjects: aplastic anemia, bone marrow failure, telomere disease and biology, telomerase, and chromosomal instability. (Source: Lattes Curriculum)
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This project aims to ensure an adequate environment for the activities developed at the Cell Therapy Center with the physical adaptation of the laboratory area, including the Hematology laboratory, cell culture room, flow cytometry laboratory, and contracting specialized services to carry out health examinations of the entire mouse colony available to the research center and acquisition o…
The Nucleus of Cellular Therapy - NuTeC will be founded on the union of the Regional Blood Center of Ribeirão Preto (Hemocentro RP) and Butantan. Hemocentro RP expertise in cellular therapy will be added to Butantan excellence in the development and production of health applied products to develop CAR T cell therapy. The activities to be conducted by NuTeC are aligned with the scope of th…
The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
The pandemia caused by the virus SARS-CoV-2 is spreading rapidly around the world, and now reached Brazil. However, its magnitude and consequences are still unknown in this country. In this study, the authors intend to evaluate the impact of convalescent plasma transfusion on patients with severe COVID-19. The clinical picture of this disease is heterogenous, with most patients with mild …
Telomeres are the repetitive nucleotide structures at the end of the linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-…
Telomeres are ribonuclear structures located at the ends of linear cromosomes that maintain genomic integrity. Germline mutations in genes involved in telomere repair and maintenance lead to excessive telomere shortening, ultimately resulting in cell senescence and/or apoptosis. In humans, telomere dysfunction manifests as disease compromising several organs, such as aplastic anemia (AA),…
Telomeres are repeated sequences of nucleotides located at the ends of linear chromosomes. Their function is to prevent the loss of genetic information due to shortening of the lagging strand during DNA replication. Functional alterations that compromise telomeric elongation or cause accelerated erosion imply serious clinical repercussions for individuals affected by these diseases, calle…
Telomeres are structures present at the end of chromosomes made up of repetitive sequences of DNA and associated proteins, whose main function is to maintain the integrity of the genome. With each cell division, telomeres progressively shorten until they reach a critical limit, so that the cell undergoes apoptosis or enters senescence. Certain cell types that have a high replicative deman…
(Only some records are available in English at this moment)
The cytotoxic T lymphocyte antigen 4 (CTLA-4) is a cellular receptor that plays a fundamental role as an immune checkpoint, responsible for regulating the immune response and preventing an attack against the body's own cells. On the other hand, tumor cells can exploit this pathway to suppress an immune response, and the CTLA-4 inhibitor ipilimumab is successfully used in the treatment of …
The hematopoietic stem cell transplantation (HSCT), or allogeneic bone marrow transplantation (BMT), has been used as treatment to a number of malignant and non-malignant diseases. It consists in the usage of hematopoietic stem cells (HSCs) mobilized from peripheral blood, bone marrow or umbilical cord blood of donors related or not with the receptor they're transferred to. After their in…
Telomeres are repetitive structures of nucleotides and regulatory proteins located at the ends of linear chromosomes whose function is the maintenance of genomic integrity. Critically short telomeres induce disruption of cell proliferation, senescence or apoptosis. In cells with high proliferative demand, the telomeric length is maintained by the enzymatic complex of the telomerase, which…
(Only some records are available in English at this moment)
In acquired immune aplastic anemia (immune AA), cytotoxic Th1 cells release cytokines that trigger changes in cell cycle and cell transcription, leading to HSC apoptosis, causing hematopoietic failure. Current treatments are limited and are hampered by the lack of compatible donors and complications. The current standard treatment is related-matched allogeneic hematopoietic stem cell tran…
Telomeres are repetitive sequences of hexanucleotides located at the ends of linear chromosomes that, when critically short, can trigger chromosomal instability, senescence, or apoptosis. Pathogenic variants in genes involved in telomere biology can lead to excessive telomere shortening and diseases most frequently affecting the bone marrow, but also the skin, lungs, liver and predisposin…
Telomeres are the repetitive nucleotide structures at the end of linear chromosomes that, when critically short, engage cell senescence, apoptosis, or chromosome instability. In cells with high proliferative demand, telomeres are repaired by telomerase, a reverse transcriptase that adds hexanucleotides to the 3' end of the DNA leading strand. In humans, germline mutations in telomere-biol…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 18 / 16 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 36 / 34 | All research grants and scholarships |
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