CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia (FO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade de São Paulo (1994), graduate at Letras from Universidade de São Paulo (2002), master's at Odontology from Universidade de São Paulo (1998) and ph.d. at Odontology from Universidade de São Paulo (2001). Has experience in Odontology, acting on the following subjects: dentistry, undernutrition and tissue repair, inflammation and alternative drugs, laser therapy and photodynamic therapy. (Source: Lattes Curriculum)
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Radiopharmaceutical drugs applied to neoplasms and autoimmune diseases can generate important side effects in the stomatognathic system, mainly sialadenitis that lead to transitory and sometimes permanent xerostomia. There are no effective protocols for the prevention and treatment of salivary gland alterations resulting from these therapies. The efficacy of photobiomodulation (PBM) for m…
Low level laser therapy has been adopted for the prevention and treatment of oral mucositis. This lesion is derived from an intense oxidative stress caused by radiotherapy and chemotherapy. The oxidative stress induces the formation of oxidized bases and activates a DNA-damage response (DDR) in neoplastic and normal cells. The DDR is composed mainly by mechanisms of non-homologous end-joi…
Oral squamous cell carcinoma (OSCC) is a high morbidity cancer, which leads high frequency of recurrence and resistance to conventional treatments. Photodynamic therapy (PDT) has been applied in early phases of OSCC, with a number of cases showing promising indexes of complete remission of the tumor. It is unknown, however, if OSCC cells can be resistant to the PDT, mainly in situations o…
The use of photodynamic therapy (PDT) in treatment of oral premalignant lesions (OPM) has been focused on recent researches. PDT is based on an electromagnetic interaction with a photo sensitizer and tissue oxygen, forming reactive oxygen species (ROS) that cause death in metabolically active cells. The aim of this study is to establish the anatomic and chronologic relationship of cellula…
(Only some records are available in English at this moment)
Oral epithelial dysplasias (OED) are potentially malignant lesions for which treatment is still debated, given the high rate of recurrence and the possibility of major tissue loss due to extensive surgical interventions. Photodynamic therapy (PDT) has been considered a promising non-surgical method for the treatment of OED, but the characterization of the mechanism of regulated necrosis (…
One of the direct effects of photobiomodulation (FBM) on the oral mucosa is the re-epithelialization in situations where tissue repair is stimulated. Recently, the duo simultaneous irradiation with 660nm and 808nm lasers has been adopted in the clinical practice of dentistry, but its mechanism of action is still poorly understood considering its effect on the cytoskeleton of keratinocytes…
Oral mucositis (OM) is an inflammatory condition derived from the cytotoxic effect of chemotherapy, mainly from 5-FU, melphalan, and methotrexate. After chemotherapy exposure, intense oxidative stress and DNA damage can occur. Photobiomodulation (PBM) is indicated for the prevention and treatment of OM, due to its properties of inflammatory modulation and repair improvement; however, the …
(Only some records are available in English at this moment)
The progression of oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) involves intricate interactions between dysplastic keratinocytes and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), particularly myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), may play a role in modulating regulated cell death (RCD) pathways, including pyroptosi…
| 1 / 1 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 7 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 13 / 12 | All research grants and scholarships |
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