CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
MEDICAL DOCTOR, PHD. Works on cardiovascular pharmacology and pharmacogenetics. (Source: Lattes Curriculum)
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Oral nitrite treatment showed benefical effects, especially in hypertension. These are partially due to nitrite or nitrate stimulared nitric oxide formation. Our lab has shonw in the last 12 years that such effects depende on acidic gastric pH, which allows the formation of nitrosothiols. This effect is prevented by treatment with omeprazole, an inhibitor of gastric acid secretion. Here, …
In contrast to what it was usually believed in the last decades, many studies carried out in the last years have shown that the anions nitrate and nitrite are not simply inert biological products of nitric oxide (NO) oxidation. In fact, nitrates are secreted by salivary glands into saliva after their absortion in the gastrointestinal system, and nitrates are reduced to nitrites by oral ba…
The advancement of knowledge of genetic variations in the human genome has allowed improved understanding of their effects on human diseases. It is well known that genetic variations may affect disease susceptibility. Genetic variations named single nucleotide polymorphisms (SNPs) are very common and are markers of important diseases. This study aims at examining the association between e…
This proposal for Dr. Schulz for the 6 months visit will be especially important for an already FAPESP-funded project Projeto individual 08/10937-1: Possíveis efeitos benéficos da inibição de metaloproteinases da matrix extracelular (MMPs) como coadjuvante de inotrópicos durante embolia pulmonar aguda - FAPESP. He will start new techniques that will lead to new data and knowledge to impro…
(Only some records are available in English at this moment)
The use of proton pump inhibitors (PPIs) has been associated with an increased risk of developing cardiovascular disease. There is evidence that PPIs increases the activity of asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide (NO). Other studies indicates that omeprazole increases the activity of xanthine oxidoreductase (XOR), promoted by ADMA, causing g…
Nitric Oxide and its metabolites the anions Nitrite (NO2-), Nitrate (NO3-), and Nitrosylated Species play a very important role in controlling the physiological maintenance of the endothelium, because NO contributes to the regulation of the cardiovascular system, such as vasodilation. The formation of NO occurs either through the activity of the enzyme nitric oxide synthase (NOS) or throu…
Systemic Arterial Hypertension (SAH) is a public health problem that affects 32.5% of the Brazilian population. This disease is often accompanied by left ventricular hypertrophy (LVH), characterized by intense remodeling of the extracellular matrix. Studies demonstrate the participation of extracellular matrix metalloproteinases (MMPs), promoting cardiac remodeling in SAH. MMPs are activa…
(Only some records are available in English at this moment)
Nitric oxide (NO) is important for cardiovascular health and its bioavailability depends on the balance between NO synthesis and NO degradation. There is evidence indicating that increased plasma free hemoglobin concentrations impair NO bioavailability causing endothelial dysfunction, increased adhesion molecule expression, platelet activation and the formation of reactive oxygen species.…
| 1 / 1 | Ongoing grants |
| 17 / 11 | Completed research grants |
| 43 / 25 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 62 / 38 | All research grants and scholarships |
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