Ricardo Weinlich

• I EINSTEIN POST-GRADUATE FORUM: RESEARCH FOR LIFE, AO.R

• Abstract

  Recently, a novel cell death pathway was identified and named necroptosis. This cell death type resembles the accidental necrosis regarding its morphology and the release of the cytoplasmic contents following the plasma membrane rupture. On the other hand, its induction and execution are biochemically controlled, and it involves the activation of the RIPK3 kinase which, in turn, activates…

  Modulation of the necroptotic pathway and its pathophysiological relevance, AP.JP

• Abstract

  A fundamental and common characteristic of all types of Cancer is the increased resistance to cell death, a characteristic that is closely related to the failure of clinical treatments and the lethality of this disease. More recently, the reduction or suppression of RIPK3 and/or MLKL expression, central molecules in the necroptosis pathway, a type of necrotic cell death, has been associat…

  The role of necroptosis pathways in pathogenesis and progression of Gliomas, BP.PD

• Abstract

  Central Nervous System (CNS) Cancers, despite their low incidence rates, are highly lethal and clinically heterogeneous tumors. The vast majority of primary CNS tumors are diagnosed as gliomas, followed by Meningiomas and other less common types such as Craniopharyngiomas, Hemangiomas and Gangliogliomas. To date, the available biomarkers are not enough to underscore the characteristics th…

  Necrotic cell death pathways & immunemodulation: identification of predictive markers in central nervous system tumors, BP.DR

• Abstract

  Necroptosis is a recently discovered, biochemically-controlled, cell death pathway that is independent of caspases and present morphological hallmarks similar to those of accidental necrosis. It can be activated by different stimuli, including death receptors and TRIF-mediated signals, and involves sequential phosphorylation of RIPK1 and RIPK3 kinases as well the MLKL pseudokinase. The ro…

  Gene modulation of RIPK3 and MLKL and its impact in the sensibility to death by necroptosis, BP.DD

(Only some records are available in English at this moment)

• Abstract

  Necroptosis is a caspase-independent cell death pathway that presents morphological hallmarks of accidental necrosis. It can be activated by different stimuli, which culminate in the activation of MLKL, the effector molecule of this pathway. Necroptosis importance has been demonstrated in many pathophysiological conditions, including bacterial and viral infections, cancer, ischemic insult…

  High throughput mapping of MLKL transcriptional regulatory elements, BE.EP.DD

• Abstract

  Several pathways can trigger different kinds of cell death, being apoptosis, pyroptosis and necroptosis the most studied ones. The first two kinds involve caspases activation, while necroptosis is caspase independent and depends on the activation of a complex that contains RIPK3 and MLKL. During viral infection, the host cell triggers its own death trying to impair the virus replication n…

  CRISPR/Cas9 tool to knockout cell death pathway genes in neuronal cells and its impact under Zika virus infection, BE.EP.PD