Abstract
Phosphatidylinositol-phosphate kinases (PIPKs) belong to a family of lipid kinase enzymes that generate various lipid messengers, including an important second messenger known as phosphatidylinositol-4,5-biphosphate, which regulates a number of cell activities, such as modulation of the actin cytoskeleton, vesicle transport, formation of focal adhesions and a variety of nuclear events. Th…