CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (FORP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1977), graduate at Odontologia from Universidade de São Paulo (1981), master's at Pharmacology from Universidade de São Paulo (1988) and ph.d. at Reabilitação Oral from Universidade de São Paulo (1994). Has experience in Odontology, focusing on Odontology, acting on the following subjects: cultura de células, osteoblastos, titânio, osteogênese and biocompatibilidade. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
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The engrailed 1 (EN1) protein belongs to a transcription factor family with DNA binding domain (homeobox) and alterations in its expression results in abnormalities in terms of development and ossification of sternum, phalanges and calvaria bones. Considering the relevance of En1 to osteogenesis, we hypothesized that this protein acts on molecular and cellular mechanisms that impacts skel…
The engrailed 1 (EN1) protein belongs to a transcription factor family with DNA binding domain (homeobox) and alterations in its expression results in abnormalities in terms of development and ossification of sternum, phalanges and calvaria bones. Considering the relevance of En1 to osteogenesis, we hypothesized that this protein acts on molecular and cellular mechanisms that impacts skel…
There is evidence that priming mesenchymal stem cells (MSCs) increase their efficacy for regenerative medicine procedures. Among the several priming methods, MSCs overexpressing growth factors, culturing MSCs on modified surfaces and MSCs treated with photobiomodulation (PBM) seem to stimulate tissue formation by MSCs. In keeping with this, the aim of this project is to evaluate the effec…
(Only some records are available in English at this moment)
Bone exhibits high healing potential but depending on the damage extension additional treatments are needed to assure tissue repair. Therapies based on cells produce meaningful bone formation; however, without inducing the complete bone regeneration. Based on evidences that modifications of cells enhance their capacity to regenerate tissues, the aim of this project is to regenerate bone u…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
Bone has a high regenerative capacity, but in some cases the extension of the lesion prevents tissue repair. In this context, cell therapy has been the focus of several research groups as an alternative to the current treatments. However, several molecular, cellular and tissue aspects were not addressed by the literature and need to be investigated in order to make cell therapy an effecti…
(Only some records are available in English at this moment)
In Dentistry and Medicine, there is often a need for bone regeneration to achieve both functional and aesthetic rehabilitation through the development of biomaterials, such as biomembranes. Recently, the research group has shown that collagen and carrageenan membranes present osteogenic potential and could be used as carriers of extracellular vesicles (EVs), including exosomes (EXOs), whi…
Extracellular vesicles (EVs) participate in complex intercellular communication mechanisms relevant to the field of Regenerative Medicine, particularly in cellular therapies utilizing mesenchymal stem cells (MSCs), as these cells can generate and release EVs into the extracellular environment. This investigation aims to examine the hypothesis that MSC-derived EVs in combination with MSCs …
Depression is a chronic mental disorder that affects over 300 million people worldwide. During episodes of depression, people experience feelings of sadness, irritability, and emptiness, as well as a loss of interest in carrying out their activities. Depression has also been associated with reduced bone mineral density, with an increased risk of fractures. Thus, the effects of depression …
(Only some records are available in English at this moment)
Cell therapy using mesenchymal stem cells (MSCs) derived from adipose tissue has been the focus of scientific investigations in the fields of Dentistry and Medicine as a promising alternative to treat bone defects. Adipose tissue-derived MSCs injected in rat calvarial defects favor bone formation, at least in part, through their secretome, which regulates the osteogeneses process. Gene-ed…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
Extracellular Vesicles (EVs) take part in sophisticated intercellular communication mechanisms relevant to the Regenerative Medicine field based on cellular therapy using Mesenchymal Stem Cells (MSCs) because these cells are able to generate and release EVs to the extracellular milieu. This study will test the hypothesis that EVs combined with MSCs induce the bone regeneration of rat calv…
(Only some records are available in English at this moment)
Osteoporosis (OP) is a bone metabolic disease which is considered a global health problem. Literature data have shown that patients taking antiresorptive drugs, such as bisphosphonates (BP), have an increased risk of developing atypical femoral fracture (AFF). The pathogenesis of AFF remains unknown, but studies in patients with OP who suffered AFFs have revealed that there is a mutation …
Particular interest in the areas of maxillofacial surgery and orthopedics is the treatment of non-union fractures. Among the myriad of available treatments, cell therapy has emerged as a promising approach but according to our results, not enough to get bone regeneration. Thus, we propose the use of gene therapy to fulfill and improve this still unmet need. For this, we selected genes inv…
Bone tissue engineering uses the combination of cells, biochemical factors and scaffolds to replace bone tissue and recover its biological functions. Among the biomaterials that have been employed as scaffolds, bioactive glasses emerge as a promising alternative, due to their ability to stimulate in vitro osteogenesis. This process may be regulated by post-transcriptional mechanisms invol…
| 5 / 5 | Ongoing grants |
| 24 / 13 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 39 / 25 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 76 / 50 | All research grants and scholarships |
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