Kelen Cristina Ribeiro Malmegrim de Farias

• Abstract

  Sickle cell disorders (SCD) refers to a set of hemoglobinopathies (hereditary disorders of hemoglobin) caused by a point mutation at position 6 of the gene encoding the chain ²-globin, leading to physical-chemical changes in the hemoglobin molecule, yielding hemoglobin (Hb) abnormally S (HbS). The form of the disease where the two encoders of ²-globin alleles are mutated (i.e. are homozyg…

  Evaluation of immune reconstitution and thymic function in sickle cell disease patients submitted to allogeneic hematopoietic stem cell transplantation, AP.R

• Abstract

  Defective apoptosis might be involved in the pathogenesis of multiple sclerosis (MS). We evaluated apoptosis-related molecules in MS patients before and after autologous hematopoietic stem cell transplantation (AHSCT) using BEAM or cyclophosphamide (CY) based conditioning regimens. Patients were followed for clinical and immunological parameters for two years after AHSCT. At baseline, MS …

  Defective expression of apoptosis-related molecules in multiple sclerosis patients is normalized early after autologous hematopoietic stem cell transplantation, PUB.ART

• Abstract

  Introduction: Type 1 diabetes mellitus (T1D) is characterized by autoimmune responses resulting in destruction of insulin-producing pancreatic beta cells. Multipotent mesenchymal stromal cells (MSCs) exhibit immunomodulatory potential, migratory capacity to injured areas and may contribute to tissue regeneration by the secretion of bioactive factors. Therefore, MSCs are considered as a pr…

  Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties, PUB.ART

(Only some records are available in English at this moment)

• Abstract

  Systemic sclerosis (ES) is an autoimmune disease of the connective tissue, characterized by microvascular lesions, associated with different degrees of fibrosis of the skin and internal organs. ES is classified into two major clinical forms; ES limited and diffuse ES. These forms are differentiated by the extent of cutaneous involvement, by the serum profile of autoantibodies and by diffe…

  Immunophenotypic, functional and gene evaluation of B cell subsets in patients with systemic sclerosis undergoing autologous hematopoietic stem cell transplantation, BP.DR

• Abstract

  Sickle cell anemia (SCA) is a monogenic disease characterized by chronic hemolytic anemia and vaso-occlusive phenomena that lead to acute painful crises and to tissue and organ, chronic and progressive damage. It is the most common monogenic hereditary disease of Brazil, occurring predominantly among African descendants, it is heterogeneously distributed being more frequent in the North a…

  Haematological and immunological mechanisms involved in the therapeutic response of patients with sickle cell anemia submitted to allogeneic hematopoietic stem cell transplantation, BP.DR

• Abstract

  Sickle cell anemia (SCA) is the most common monogenic disease in the world , with important clinical, epidemiological and social impact. In Brazil, is the most common hereditary disease, occurring predominantly among Afrodescendants. The disease is characterized by chronic hemolytic anemia, chronic inflammatory and procoagulant state, and vaso-occlusive phenomena that lead to acute painfu…

  Evaluation of thymic function in patients with sickle cell anemia, BP.DR

(Only some records are available in English at this moment)

• Abstract

  Autologous hematopoietic stem cell transplantation (AHSCT) has emerged as a novel therapy for systemic sclerosis (SSc) patients and induces long-term disease remission. In the last years, few works have reported the reconstitution of B-cell subsets after AHSCT. However, the assessment of B-cell receptor (BCR) diversity after AHSCT needs to be ascertained. Preliminary results of our group …

  Evaluation of B-cell receptor repertoire in systemic sclerosis patients treated with autologous hematopoietic stem cell transplantation, BE.EP.DR

• Resumo

  Sickle cell anemia (SCA) is a hereditary chronic condition disorder of hemoglobin (Hb) caused by a single missense mutation in the human ²-globin gene, resulting in the formation of an abnormal hemoglobin (HbS). The polymerization of the HbS under hypoxic conditions is a key event in the complex pathophysiology of SCA. In Brazil, it is related one new case of SCA in every 1000 births, sho…

  Evaluation of the Thymic Function in patients with sickle cell anemia following hematopoietic stem cell transplantation and conventionally treated, BE.EP.DR